ArticleMolecular neurobiology2016
MAOA Variants and Genetic Susceptibility to Major Psychiatric Disorders.
Article in Molecular neurobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- A sum of its parts: A systematic review evaluating biopsychosocial and behavioral determinants of perinatal depression.PloS one · 2024Pooled it
- Genetic association and meta-analysis of a schizophrenia GWAS variant rs10489202 in East Asian populations.Translational psychiatry · 2018Pooled it
- Common variants at 2q11.2, 8q21.3, and 11q13.2 are associated with major mood disorders.Translational psychiatry · 2017Pooled it
- Evaluation of European Schizophrenia GWAS Loci in Asian Populations via Comprehensive Meta-Analyses.Molecular neurobiology · 2017Pooled it
- Psychopathic Traits Associate With Later Schizophrenia.Acta psychiatrica Scandinavica · 2025Article
- Association of Monoamine Oxidase A Gene Promoter Region (30 bp μVNTR) Polymorphism with Serum Levels in Multiple Psychiatric Disorders.Biomedicines · 2025Article
- A sum of its parts: A systematic review evaluating biopsychosocial and behavioral determinants of perinatal depression.medRxiv : the preprint server for health sciences · 2023Article
- Impact of genetic variants within serotonin turnover enzymes on human cerebral monoamine oxidase A in vivo.Translational psychiatry · 2023Article
- Revisiting tandem repeats in psychiatric disorders from perspectives of genetics, physiology, and brain evolution.Molecular psychiatry · 2022Review
- Roles of Hostility and Depression in the Association between the MAOA Gene Polymorphism and Internet Gaming Disorder.International journal of environmental research and public health · 2021Article
- Translational genomics and beyond in bipolar disorder.Molecular psychiatry · 2021Review
- Depressive Symptoms among Middle-Aged Women-Understanding the Cause.Brain sciences · 2020Article
- The role of monoamine oxidase A in HPV-16 E7-induced epithelial-mesenchymal transition and HIF-1α protein accumulation in non-small cell lung cancer cells.International journal of biological sciences · 2020Article
- MAOA-VNTR genotype affects structural and functional connectivity in distributed brain networks.Human brain mapping · 2019Article
- Emotional stability is associated with the MAOA promoter uVNTR polymorphism in women.Brain and behavior · 2019Article
- Interactions between monoamine oxidase A rs1137070 and smoking on brain structure and function in male smokers.The European journal of neuroscience · 2019Article
- Review
- The cAMP responsive element-binding (CREB)-1 gene increases risk of major psychiatric disorders.Molecular psychiatry · 2018Article
- Association of Monoamine Oxidase A (MAOA) Gene uVNTR and rs6323 Polymorphisms with Attention Deficit and Hyperactivity Disorder in Korean Children.Medicina (Kaunas, Lithuania) · 2018Article
- Increased expression of monoamine oxidase A is associated with epithelial to mesenchymal transition and clinicopathological features in non-small cell lung cancer.Oncology letters · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the metabolism of several biological amines such as dopamine, norepinephrine, and serotonin, which are important neurochemicals in the pathogenesis of major psychiatric illnesses. MAOA is regarded as a functional plausible susceptibility gene for psychiatric disorders, whereas previous hypothesis-driven association studies obtained controversial results, a reflection of small sample size, genetic heterogeneity, or true negative associations. In addition, MAOA is not analyzed in most of genome-wide association studies (GWAS) on psychiatric disorders, since it is located on Chromosome Xp11.3. Therefore, the effects of MAOA variants on genetic predisposition to psychiatric disorders remain obscure. To fill this gap, we collected psychiatric phenotypic (schizophrenia, bipolar disorder, and major depressive disorder) and genetic data in up to 18,824 individuals from diverse ethnic groups. We employed classical fixed (or random) effects inverse variance weighted methods to calculate summary odds ratios (OR) and 95 % confidence intervals (CI). We identified a synonymous SNP rs1137070 showing significant associations with major depressive disorder (p = 0.00067, OR = 1.263 for T allele) and schizophrenia (p = 0.0039, OR = 1.225 for T allele) as well as a broad spectrum of psychiatric phenotype (p = 0.000066, OR = 1.218 for T allele) in both males and females. The effect size was similar between different ethnic populations and different gender groups. Collectively, we confirmed that MAOA is a risk gene for psychiatric disorders, and our results provide useful information toward a better understanding of genetic mechanism involving MAOA underlying risk of complex psychiatric disorders.
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Registered trials
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