ArticleScientific reports2015
Simultaneously targeting inflammatory response and parasite sequestration in brain to treat Experimental Cerebral Malaria.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- A Systematic Review of Curcumin and its Derivatives as Valuable Sources of Antileishmanial Agents.Acta parasitologica · 2021Pooled it
- Oral Therapy Using a Combination of Nanotized Antimalarials and Immunomodulatory Molecules Reduces Inflammation and Prevents Parasite Induced Pathology in the Brain and Spleen ofFrontiers in immunology · 2021Article
- The Potential use of a Curcumin-Piperine Combination as an Antimalarial Agent: A Systematic Review.Journal of tropical medicine · 2021Review
- Article
- Treatment of Experimental Cerebral Malaria by Slow Release of Artemisone From Injectable Pasty Formulation.Frontiers in pharmacology · 2020Article
- Melatonin Prevents Brain Damage and Neurocognitive Impairment Induced byFrontiers in cellular and infection microbiology · 2020Article
- Signatures of divergent anti-malarial treatment responses in peripheral blood from adults and young children in Malawi.Malaria journal · 2019Article
- Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer Cells.Immunity · 2018Article
- Adjunctive therapy for severe malaria: a review and critical appraisal.Malaria journal · 2018Review
- Nanocurcumin is superior to native curcumin in preventing degenerative changes in Experimental Cerebral Malaria.Scientific reports · 2017Article
- Young Sprague Dawley rats infected by Plasmodium berghei: A relevant experimental model to study cerebral malaria.PloS one · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Malaria afflicts around 200 million people annually, with a mortality number close to 600,000. The mortality rate in Human Cerebral Malaria (HCM) is unacceptably high (15-20%), despite the availability of artemisinin-based therapy. An effective adjunct therapy is urgently needed. Experimental Cerebral Malaria (ECM) in mice manifests many of the neurological features of HCM. Migration of T cells and parasite-infected RBCs (pRBCs) into the brain are both necessary to precipitate the disease. We have been able to simultaneously target both these parameters of ECM. Curcumin alone was able to reverse all the parameters investigated in this study that govern inflammatory responses, CD8(+) T cell and pRBC sequestration into the brain and blood brain barrier (BBB) breakdown. But the animals eventually died of anemia due to parasite build-up in blood. However, arteether-curcumin (AC) combination therapy even after the onset of symptoms provided complete cure. AC treatment is a promising therapeutic option for HCM.
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