ArticleScientific reports2015
TRPA1 mediates the hypothermic action of acetaminophen.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 49 citations in OpenAlex.
- Paracetamol sharpens reflection and spatial memory: a double-blind randomized controlled study in healthy volunteers.Drug design, development and therapy · 2016Trial
- The analgesic paracetamol metabolite AM404 acts peripherally to directly inhibit sodium channels.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Paracetamol: the potential therapeutic pathways defining its clinical use.Inflammopharmacology · 2025Review
- Transient Receptor Potential Ankyrin-1-expressing vagus nerve fibers mediate IL-1β induced hypothermia and reflex anti-inflammatory responses.Molecular medicine (Cambridge, Mass.) · 2023Article
- Nobel somatosensations and pain.Pflugers Archiv : European journal of physiology · 2022Review
- Extract ofMolecules (Basel, Switzerland) · 2021Article
- Paracetamol (Acetaminophen) and the Developing Brain.International journal of molecular sciences · 2021Review
- The Hypothermic Effect of Hydrogen Sulfide Is Mediated by the Transient Receptor Potential Ankyrin-1 Channel in Mice.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Striatal TRPV1 activation by acetaminophen ameliorates dopamine D2 receptor antagonist-induced orofacial dyskinesia.JCI insight · 2021Article
- Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation.Nature communications · 2021Article
- Paracetamol (acetaminophen): A familiar drug with an unexplained mechanism of action.Temperature (Austin, Tex.) · 2021Review
- Analgesic Effect of Acetaminophen: A Review of Known and Novel Mechanisms of Action.Frontiers in pharmacology · 2020Review
- Modification of TRPV4 activity by acetaminophen.Heliyon · 2020Article
- New approaches and challenges to targeting the endocannabinoid system.Nature reviews. Drug discovery · 2018Review
- An insight into paracetamol and its metabolites using molecular docking and molecular dynamics simulation.Journal of molecular modeling · 2018Article
- Mammalian cold TRP channels: impact on thermoregulation and energy homeostasis.Pflugers Archiv : European journal of physiology · 2018Review
- Acetaminophen Relieves Inflammatory Pain through CBThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- H89 dihydrochloride hydrate and calphostin C lower the body temperature through TRPV1.Molecular medicine reports · 2018Article
- Effects of metamizole, MAA, and paracetamol on proliferation, apoptosis, and necrosis in the pancreatic cancer cell lines PaTu 8988 t and Panc-1.BMC pharmacology & toxicology · 2017Article
- Reactive metabolites of acetaminophen activate and sensitize the capsaicin receptor TRPV1.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acetaminophen (APAP) is an effective antipyretic and one of the most commonly used analgesic drugs. Unlike antipyretic non-steroidal anti-inflammatory drugs, APAP elicits hypothermia in addition to its antipyretic effect. Here we have examined the mechanisms responsible for the hypothermic activity of APAP. Subcutaneous, but not intrathecal, administration of APAP elicited a dose dependent decrease in body temperature in wildtype mice. Hypothermia was abolished in mice pre-treated with resiniferatoxin to destroy or defunctionalize peripheral TRPV1-expressing terminals, but resistant to inhibition of cyclo-oxygenases. The hypothermic activity was independent of TRPV1 since APAP evoked hypothermia was identical in wildtype and Trpv1(-/-) mice, and not reduced by administration of a maximally effective dose of a TRPV1 antagonist. In contrast, a TRPA1 antagonist inhibited APAP induced hypothermia and APAP was without effect on body temperature in Trpa1(-/-) mice. In a model of yeast induced pyrexia, administration of APAP evoked a marked hypothermia in wildtype and Trpv1(-/-) mice, but only restored normal body temperature in Trpa1(-/-) and Trpa1(-/-)/Trpv1(-/-) mice. We conclude that TRPA1 mediates APAP evoked hypothermia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.