Trial reportScientific reports2015
γ-Aminobutyric acid (GABA) administration improves action selection processes: a randomised controlled trial.
Trial report in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- The Effects of FermentedEvidence-based complementary and alternative medicine : eCAM · 2018Trial
- Influences of glutamine administration on response selection and sequence learning: a randomized-controlled trial.Scientific reports · 2017Trial
- Production and quality evaluation of a novel γ-aminobutyric acid-enriched yogurt.Frontiers in nutrition · 2024Article
- An Oppositional Tolerance Account for Potential Cognitive Deficits Caused by the Discontinuation of Antidepressant Drugs.Pharmacopsychiatry · 2021Article
- Hormonal and Neurological Aspects of Dog Walking for Dog Owners and Pet Dogs.Animals : an open access journal from MDPI · 2021Article
- GABA Supplementation Negatively Affects Cognitive Flexibility Independent of Tyrosine.Journal of clinical medicine · 2021Article
- Neurochemistry of Visual Attention.Frontiers in neuroscience · 2021Review
- Hacking the Brain: Dimensions of Cognitive Enhancement.ACS chemical neuroscience · 2019Review
- Review
- Eating for 3.8 × 10Frontiers in endocrinology · 2018Review
- Corticospinal Plasticity in Bilateral Primary Motor Cortices Induced by Paired Associative Stimulation to the Dominant Hemisphere Does Not Differ between Young and Older Adults.Neural plasticity · 2017Article
- The Neuro-endocrinological Role of Microbial Glutamate and GABA Signaling.Frontiers in microbiology · 2016Review
- Neurotransmitters as food supplements: the effects of GABA on brain and behavior.Frontiers in psychology · 2015Review
- Article
Corrections and comments
- Retraction · 2022-05-25Concerns/Issues about Data · Investigation by Company/Institution · Unreliable Results and/or Conclusions ·
- Retracted
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to accomplish a task goal, real-life environments require us to develop different action control strategies in order to rapidly react to fast-moving visual and auditory stimuli. When engaging in complex scenarios, it is essential to prioritise and cascade different actions. Recent studies have pointed to an important role of the gamma-aminobutyric acid (GABA)-ergic system in the neuromodulation of action cascading. In this study we assessed the specific causal role of the GABA-ergic system in modulating the efficiency of action cascading by administering 800 mg of synthetic GABA or 800 mg oral of microcrystalline cellulose (placebo). In a double-blind, randomised, between-group design, 30 healthy adults performed a stop-change paradigm. Results showed that the administration of GABA, compared to placebo, increased action selection when an interruption (stop) and a change towards an alternative response were required simultaneously, and when such a change had to occur after the completion of the stop process. These findings, involving the systemic administration of synthetic GABA, provide the first evidence for a possible causal role of the GABA-ergic system in modulating performance in action cascading.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.