Evidence map›Paper›PMID 26227344›Full record

ArticleLasers in surgery and medicine2015

Targeted narrowband intense pulsed light on cutaneous vasculature.

Wesley J Moy, Joshua D Yakel, O Cecilia Osorio, Jocelynda Salvador, Carole Hayakawa, Kristen M Kelly, Bernard Choi

Abstract readComparative StudyEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Lasers in surgery and medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Wesley J MoyBeckman Laser Institute and Medical Clinic, University of California, Irvine, California.
Joshua D YakelBeckman Laser Institute and Medical Clinic, University of California, Irvine, California.
O Cecilia OsorioBeckman Laser Institute and Medical Clinic, University of California, Irvine, California.
Jocelynda SalvadorBeckman Laser Institute and Medical Clinic, University of California, Irvine, California.
Carole HayakawaBeckman Laser Institute and Medical Clinic, University of California, Irvine, California.
Kristen M KellyBeckman Laser Institute and Medical Clinic, University of California, Irvine, California.
Bernard ChoiBeckman Laser Institute and Medical Clinic, University of California, Irvine, California.
Beckman Laser Institute and Medical Clinic · USUniversity of California, Irvine · USEdwards Lifesciences (United States) · USIrvine University · US

Funding

Virtual Photonocs TechnologiesP41EB015890 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI TROMBERG, BRUCE J. · 2012 to 2017
$7.0M
Novel Optical Treatment Approach for Vascular BirthmarksR01HD065536 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHOI, BERNARD, KELLY, KRISTEN M · 2010 to 2014
$1.4M
A Virtual Tissue Simulator for Biomedical OpticsK25EB007309 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI HAYAKAWA, CAROLE KAY · 2008 to 2012
$559k
NIBIB NIH HHS K25 EB007309NIBIB NIH HHS K25-EB007309NIBIB NIH HHS P41 EB015890NIBIB NIH HHS P41EB015890NICHD NIH HHS R01 HD065536NICHD NIH HHS R01HD065536
6 · The paper itself

Abstract

BACKGROUND AND

objectivesLaser based therapies are the standard treatment protocol for port wine stain in the United States, but complete removal is infrequently achieved. Intense pulsed light (IPL) offers a broadband light spectrum approach as a viable treatment alternative. Previous studies suggest that IPL can be more effective in treatment of port wine stain by utilizing multiple wavelengths to selectively target different peaks in oxy- and deoxy-hemoglobin. Our study objectives were to (i) determine a characteristic radiant exposure able to achieve persistent vascular shutdown with narrowband IPL irradiation, (ii) determine the degree to which narrowband IPL irradiation can achieve persistent vascular shutdown, and (iii) compare the effectiveness of narrowband IPL radiation to single wavelength pulsed dye laser (PDL) irradiation in achieving persistent vascular shutdown. STUDY DESIGN/MATERIALS AND

methodsWe utlized either single pulse or double, stacked pulses in narrowband IPL experiments, with the IPL operating over a 500-600 nm wavelength range on the rodent dorsal window chamber model. We compared the results from our narrowband IPL experiments to acquired PDL data from a previous study and determined that narrowband IPL treatments can also produce persistent vascular shutdown. We ran Monte Carlo simulations to investigate the relationship between absorbed energy, wavelength, and penetration depth.

resultsFor single and double pulse narrowband IPL irradiation we observed (i) little to no change in blood flow, resulting in no persistent vascular shutdown, (ii) marked acute disruption in blood flow and vascular structure, followed by partial to full recovery of blood flow, also resulting in no persistent vascular shutdown, and (iii) immediate changes in blood flow and vascular structure, resulting in prolonged and complete vascular shutdown. Monte Carlo modeling resulted in a 53.2% and 69.0% higher absorbed energy distribution in the top half and the total simulated vessel when comparing the composite narrowband IPL to the 595 nm (PDL), respectively.

conclusionsOur data collectively demonstrate the potential to achieve removal of vascular lesions using a 500-600 nm range. Additionally, the narrowband IPL was tuned to optimize a specific wavelength range that can be used to treat PWS, whereas the PDL can only operate at one discrete wavelength.

Indexed as

AnimalsIntense Pulsed Light TherapyLasers, DyeMiceMice, Inbred C3HMonte Carlo MethodPort-Wine StainRandom AllocationSkinLaser speckle imagingPhotocoagulationphotothermolysisPhotothrombosisSelective

Identifiers

PMID26227344
PMCPMC4596886
OpenAlexW1916547447

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.