Evidence map›Paper›PMID 26227016›Full record

Observational studyClinical transplantation2015

Gender differences in use of prescription narcotic medications among living kidney donors.

Krista L Lentine, Ngan N Lam, Mark A Schnitzler, Amit X Garg, Huiling Xiao, Sheila E Leander, Daniel C Brennan, Sandra J Taler, David Axelrod, Dorry L Segev

Abstract readObservational Study
In one paragraph

Observational study in Clinical transplantation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Antidepressant medication use before and after kidney transplant: implications for outcomes - a retrospective study.Transplant international : official journal of the European Society for Organ Transplantation · 2018
    Article
  5. Validation of Living Donor Nephrectomy Codes.Canadian journal of kidney health and disease · 2018
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Krista L LentineCenter for Outcomes Research, Saint Louis University School of Medicine, St. Louis, MO, USA.
Ngan N LamDivision of Nephrology, University of Alberta, Edmonton, AB, Canada.
Mark A SchnitzlerCenter for Outcomes Research, Saint Louis University School of Medicine, St. Louis, MO, USA.
Amit X GargDivision of Nephrology, Western University, London, ON, Canada.
Huiling XiaoCenter for Outcomes Research, Saint Louis University School of Medicine, St. Louis, MO, USA.
Sheila E LeanderSaint Louis University School of Nursing, St. Louis, MO, USA.
Daniel C BrennanTransplant Nephrology, Washington University School of Medicine, St. Louis, MO, USA.
Sandra J TalerDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
David AxelrodDivision of Abdominal Transplantation, Department of Surgery, Dartmouth Hitchcock Medical Center, Hanover, NH, USA.
Dorry L SegevDivision of Abdominal Transplantation, Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Funding

Long-Term Health Outcomes After Live Kidney Donation in African AmericansR01DK096008 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2013 to 2017
$3.8M
Patient Oriented Research in Kidney Disease and Transplant SurgeryK24DK101828 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2014 to 2018
$922k
NIDDK NIH HHS K24 DK101828NIDDK NIH HHS K24-DK101828NIDDK NIH HHS R01 DK096008NIDDK NIH HHS R01-DK096008
6 · The paper itself

Abstract

Prescription narcotic use among living kidney donors is not well described. Using a unique database that integrates national registry identifiers for living kidney donors (1987-2007) in the United States with billing claims from a private health insurer (2000-2007), we identified pharmacy fills for prescription narcotic medications in periods 1-4 and >4 yr post-donation and estimated relative likelihoods of post-donation narcotic use by Cox regression. We also compared narcotic fill rates and medication possession ratios (MPRs, defined as (days of medication supplied)/(days observed)), between donors and age- and sex-matched non-donors. Overall, rates of narcotic medication fills were 32.3 and 32.4 per 100 person-years in periods 1-4 and >4 yr post-donation. After age and race adjustment, women were approximately twice as likely as men to fill a narcotic prescription in years 1-4 (adjusted hazard ratio, aHR, 2.28; 95% confidence interval, CI, 1.86-2.79) and >4 yr (aHR 1.70; 95% CI 1.50-1.93). MPRs in donors were low (<2.5% days exposed), and lower than among age- and sex-matched non-donors. Prescription narcotic medication use is more common among women than men in the intermediate term after live kidney donation. Overall, total narcotic exposure is low, and lower than among non-donors from the general population.

Indexed as

Kidney TransplantationNarcoticsNephrectomyAdultAgedDrug UtilizationFemaleFollow-Up StudiesHumansLiving DonorsMaleMatched-Pair AnalysisMiddle AgedProportional Hazards ModelsRegistriesRetrospective StudiesNarcoticsadministrative claims datahealth outcomesliving kidney donorsnarcotic medicationpharmacy claims

Identifiers

PMID26227016
PMCPMC4805522

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.