ArticleMolecular biology and evolution2015
BMD Loci Contribute to Ethnic and Developmental Differences in Skeletal Fragility across Populations: Assessment of Evolutionary Selection Pressures.
Article in Molecular biology and evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- A Meta-Analysis of the Transferability of Bone Mineral Density Genetic Loci Associations From European to African Ancestry Populations.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021Pooled it
- The SINTER study: a recall-by-genotype design with multidimensional musculoskeletal phenotyping across internal-medicine outpatient clinics.European journal of epidemiology · 2026Article
- Mandibular Cortical Thickness Predicts Skull BMD in Adolescents.Calcified tissue international · 2026Article
- Genetic and epidemiologic assessment of mandibular cortical indices and bone mineral density in peripubertal children: the Generation R study.Clinical oral investigations · 2025Article
- Race-neutral Pediatric Reference Ranges for Bone Mineral Density Predict Prospective Fractures in Childhood.The Journal of clinical endocrinology and metabolism · 2025Article
- Bridging Genomic Research Disparities in Osteoporosis GWAS: Insights for Diverse Populations.Current osteoporosis reports · 2025Review
- Evolutionary and functional analyses of LRP5 in archaic and extant modern humans.Human genomics · 2024Article
- BoneXpert-derived bone health index reference curves constructed on healthy Indian children and adolescents.Pediatric radiology · 2024Article
- Ancient DNA suggests anaemia and low bone mineral density as the cause for porotic hyperostosis in ancient individuals.Scientific reports · 2023Article
- Telomere length as a marker of changes in body composition and fractures-an analysis of data from the NHANES 2001-2002.Frontiers in immunology · 2023Article
- Article
- The Polygenic and Monogenic Basis of Paediatric Fractures.Current osteoporosis reports · 2021Review
- Genetic ancestry and skeletal toxicities among childhood acute lymphoblastic leukemia patients in the DFCI 05-001 cohort.Blood advances · 2021Article
- Dual-energy X-ray absorptiometry bone densitometry in pediatrics: a practical review and update.Pediatric radiology · 2021Review
- Diversity, compositional and functional differences between gut microbiota of children and adults.Scientific reports · 2020Article
- Evolutionary Perspectives on the Developing Skeleton and Implications for Lifelong Health.Frontiers in endocrinology · 2020Review
- Antagonistic Pleiotropy in Human Disease.Journal of molecular evolution · 2020Review
- Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bone mineral density.Nature communications · 2019Article
- Ancestry and dental development: A geographic and genetic perspective.American journal of physical anthropology · 2018Article
- Widespread signatures of positive selection in common risk alleles associated to autism spectrum disorder.PLoS genetics · 2017Article
Corrections and comments
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Authors and funding
18 authors at 7 institutions in 2 countries.
Funding
Abstract
Bone mineral density (BMD) is a highly heritable trait used both for the diagnosis of osteoporosis in adults and to assess bone health in children. Ethnic differences in BMD have been documented, with markedly higher levels in individuals of African descent, which partially explain disparity in osteoporosis risk across populations. To date, 63 independent genetic variants have been associated with BMD in adults of Northern-European ancestry. Here, we demonstrate that at least 61 of these variants are predictive of BMD early in life by studying their compound effect within two multiethnic pediatric cohorts. Furthermore, we show that within these cohorts and across populations worldwide the frequency of those alleles associated with increased BMD is systematically elevated in individuals of Sub-Saharan African ancestry. The amount of differentiation in the BMD genetic scores among Sub-Saharan and non-Sub-Saharan populations together with neutrality tests, suggest that these allelic differences are compatible with the hypothesis of selective pressures acting on the genetic determinants of BMD. These findings constitute an explorative contribution to the role of selection on ethnic BMD differences and likely a new example of polygenic adaptation acting on a human trait.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.