Evidence map›Paper›PMID 26226938›Full record

Trial reportBrain stimulation

High-Definition and Non-invasive Brain Modulation of Pain and Motor Dysfunction in Chronic TMD.

Adam Donnell, Thiago D Nascimento, Mara Lawrence, Vikas Gupta, Tina Zieba, Dennis Q Truong, Marom Bikson, Abhi Datta, Emily Bellile, Alexandre F DaSilva

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 4 pooled it
5.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 4 syntheses or guidelines pooled it, 71 citations in OpenAlex.

  1. Pooled it
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  3. Non-invasive brain stimulation techniques for chronic pain.The Cochrane database of systematic reviews · 2018
    Pooled it
  4. Non-invasive brain stimulation techniques for chronic pain.The Cochrane database of systematic reviews · 2018
    Pooled it
  5. High-definition tDCS over primary motor cortex modulates brain signal variability and functional connectivity in episodic migraine.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024
    Trial
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  8. Functional Magnetic Resonance Imaging Signal Variability Is Associated With Neuromodulation in Fibromyalgia.Neuromodulation : journal of the International Neuromodulation Society · 2023
    Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Adam DonnellHeadache & Orofacial Pain Effort (H.O.P.E.), Biological & Materials Sciences Department, University of Michigan School of Dentistry, USA; Department of Orthodontics & Pediatric Dentistry, School of Dentistry, University of Michigan, USA.
Thiago D NascimentoHeadache & Orofacial Pain Effort (H.O.P.E.), Biological & Materials Sciences Department, University of Michigan School of Dentistry, USA.
Mara LawrenceHeadache & Orofacial Pain Effort (H.O.P.E.), Biological & Materials Sciences Department, University of Michigan School of Dentistry, USA.
Vikas GuptaHeadache & Orofacial Pain Effort (H.O.P.E.), Biological & Materials Sciences Department, University of Michigan School of Dentistry, USA.
Tina ZiebaHeadache & Orofacial Pain Effort (H.O.P.E.), Biological & Materials Sciences Department, University of Michigan School of Dentistry, USA.
Dennis Q TruongDepartment of Biomedical Engineering, The City College of New York, City University of New York, New York, NY, USA.
Marom BiksonDepartment of Biomedical Engineering, The City College of New York, City University of New York, New York, NY, USA.
Abhi DattaSoterix Medical, New York, NY, USA.
Emily BellileDepartment of Biostatistics, School of Public Health, University of Michigan, USA.
Alexandre F DaSilvaHeadache & Orofacial Pain Effort (H.O.P.E.), Biological & Materials Sciences Department, University of Michigan School of Dentistry, USA; Molecular & Behavioral Neuroscience Institute (MBNI), University of Michigan, USA. Electronic address: adasilva@umich.edu.
University of Michigan–Ann Arbor · USCity College of New York · USSoterix Medical (United States) · US

Funding

Brain as a Research and Therapeutic Target in Chronic TMDR56DE022637 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DASILVA, ALEXANDRE · 2013 to 2014
$773k
NIDCR NIH HHS R56 DE022637
6 · The paper itself

Abstract

backgroundTemporomandibular disorders (TMD) have a high prevalence and in many patients pain and masticatory dysfunction persist despite a range of treatments. Non-invasive brain neuromodulatory methods, namely transcranial direct current stimulation (tDCS), can provide relatively long-lasting pain relief in chronic pain patients.

objectiveTo define the neuromodulatory effect of five daily 2x2 motor cortex high-definition tDCS (HD-tDCS) sessions on clinical pain and motor measures in chronic TMD patients. It is predicted that M1 HD-tDCS will selectively modulate clinical measures, by showing greater analgesic after-effects compared to placebo, and active treatment will increase pain free jaw movement more than placebo.

methodsTwenty-four females with chronic myofascial TMD pain underwent five daily, 20-min sessions of active or sham 2 milliamps (mA) HD-tDCS. Measurable outcomes included pain-free mouth opening, visual analog scale (VAS), sectional sensory-discriminative pain measures tracked by a mobile application, short form of the McGill Pain Questionnaire, and the Positive and Negative Affect Schedule. Follow-up occurred at one-week and four-weeks post-treatment.

resultsThere were significant improvements for clinical pain and motor measurements in the active HD-tDCS group compared to the placebo group for: responders with pain relief above 50% in the VAS at four-week follow-up (P = 0.04); pain-free mouth opening at one-week follow-up (P < 0.01); and sectional pain area, intensity and their sum measures contralateral to putative M1 stimulation during the treatment week (P < 0.01). No changes in emotional values were shown between groups.

conclusionPutative M1 stimulation by HD-tDCS selectively improved meaningful clinical sensory-discriminative pain and motor measures during stimulation, and up to four-weeks post-treatment in chronic myofascial TMD pain patients.

Indexed as

AdultAgedBrainChronic PainFemaleFollow-Up StudiesHumansMiddle AgedMotor CortexMotor Skills DisordersPain ManagementPain MeasurementSingle-Blind MethodTemporomandibular Joint DisordersTranscranial Direct Current StimulationClinical trialPainPainTrekTemporomandibular disorderTranscranial direct current stimulation

Identifiers

PMID26226938
PMCPMC4656049
OpenAlexW964324286

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.