Evidence map›Paper›PMID 26226656›Full record

ArticleHormones and behavior2015

Sex differences in diurnal rhythms of food intake in mice caused by gonadal hormones and complement of sex chromosomes.

Xuqi Chen, Lixin Wang, Dawn H Loh, Christopher S Colwell, Yvette Taché, Karen Reue, Arthur P Arnold

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hormones and behavior, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 71 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. The impact of chromosomal sex on cardiometabolic health and disease.Trends in endocrinology and metabolism: TEM · 2023
    Review
  5. The evolutionary impact and influence of oestrogens on adipose tissue structure and function.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Estrogens and the circadian system.Seminars in cell & developmental biology · 2022
    Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Sexes on the brain: Sex as multiple biological variables in the neuronal control of feeding.Biochimica et biophysica acta. Molecular basis of disease · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Xuqi ChenDepartment of Integrative Biology & Physiology, University of California, Los Angeles, CA, USA; Laboratory of Neuroendocrinology of the Brain Research Institute, University of California, Los Angeles, CA, USA. Electronic address: xuqichen@physci.ucla.edu.
Lixin WangCURE/Digestive Diseases Research Center and Center for the Neurobiology of Stress, Department of Medicine, Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; VA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd, Los Angeles, CA, 90073, USA. Electronic address: LixinWang@mednet.ucla.edu.
Dawn H LohLaboratory of Neuroendocrinology of the Brain Research Institute, University of California, Los Angeles, CA, USA; Department of Psychiatry and Biobehavioral Sciences, Semel Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. Electronic address: hloh@mednet.ucla.edu.
Christopher S ColwellLaboratory of Neuroendocrinology of the Brain Research Institute, University of California, Los Angeles, CA, USA; Department of Psychiatry and Biobehavioral Sciences, Semel Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. Electronic address: ccolwell@mednet.ucla.edu.
Yvette TachéCURE/Digestive Diseases Research Center and Center for the Neurobiology of Stress, Department of Medicine, Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; VA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd, Los Angeles, CA, 90073, USA. Electronic address: ytache@mednet.ucla.edu.
Karen ReueDepartment of Human Genetics and Molecular Biology Institute, David Geffen School of Medicine at UCLA, Los Angeles CA, USA. Electronic address: reuek@ucla.edu.
Arthur P ArnoldDepartment of Integrative Biology & Physiology, University of California, Los Angeles, CA, USA; Laboratory of Neuroendocrinology of the Brain Research Institute, University of California, Los Angeles, CA, USA. Electronic address: arnold@ucla.edu.
University of California, Los Angeles · USCenter for Digestive and Liver Diseases · US

Funding

Pilot and Feasibility ProgramP30DK041301 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROZENGURT, JUAN ENRIQUE · 1990 to 2019
$18.0M
Sex Chromosome Effects on Neural DevelopmentR01NS043196 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARNOLD, ARTHUR P · 2003 to 2013
$3.4M
Sex differences in obesity and metabolic diseaseR01DK083561 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARNOLD, ARTHUR P, CHEN, XUQI · 2010 to 2014
$1.6M
X chromosome dosage and metabolic diseaseR56DK083561 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARNOLD, ARTHUR P, REUE, KAREN · 2016 to 2016
$154k
NIDDK NIH HHS DK041301NIDDK NIH HHS DK083561NIDDK NIH HHS P30 DK041301NIDDK NIH HHS R01 DK083561NIDDK NIH HHS R56 DK083561NINDS NIH HHS NS043196NINDS NIH HHS R01 NS043196
6 · The paper itself

Abstract

We measured diurnal rhythms of food intake, as well as body weight and composition, while varying three major classes of sex-biasing factors: activational and organizational effects of gonadal hormones, and sex chromosome complement (SCC). Four Core Genotypes (FCG) mice, comprising XX and XY gonadal males and XX and XY gonadal females, were either gonad-intact or gonadectomized (GDX) as adults (2.5months); food intake was measured second-by-second for 7days starting 5weeks later, and body weight and composition were measured for 22weeks thereafter. Gonadal males weighed more than females. GDX increased body weight/fat of gonadal females, but increased body fat and reduced body weight of males. After GDX, XX mice had greater body weight and more fat than XY mice. In gonad-intact mice, males had greater total food intake and more meals than females during the dark phase, but females had more food intake and meals and larger meals than males during the light phase. GDX reduced overall food intake irrespective of gonad type or SCC, and eliminated differences in feeding between groups with different gonads. Diurnal phase of feeding was influenced by all three sex-biasing variables. Gonad-intact females had earlier onset and acrophase (peak) of feeding relative to males. GDX caused a phase-advance of feeding, especially in XX mice, leading to an earlier onset of feeding in GDX XX vs. XY mice, but earlier acrophase in GDX males relative to females. Gonadal hormones and SCC interact in the control of diurnal rhythms of food intake.

Indexed as

Circadian RhythmSex CharacteristicsAnimalsBody CompositionBody WeightEatingFemaleGenotypeGonadal HormonesMaleMiceMice, Inbred C57BLMice, TransgenicSex ChromosomesSex FactorsGonadal HormonesAdiposityBody compositionCircadian rhythmEstradiolFood intakeFour Core GenotypesNight eatingObesitySex chromosomesSex differencesTestosterone

Identifiers

PMID26226656
PMCPMC4648666
OpenAlexW989035051

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.