ArticleThe Journal of infection2015
Genomic resolution of an aggressive, widespread, diverse and expanding meningococcal serogroup B, C and W lineage.
Article in The Journal of infection, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers, 1 of them a synthesis that pooled it.
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Who cites it
118 citing papers in PubMed, 1 synthesis or guideline pooled it, 223 citations in OpenAlex.
- Atypical presentation of invasive meningococcal disease caused by serogroup W meningococci.Epidemiology and infection · 2020Pooled it
- Abdominal symptoms of invasive meningococcal disease are associated with the induction of plasminogen activator inhibitor-1 in omental adipocytes.BMC infectious diseases · 2026Article
- Genomic and evolutionary insights into a novelMicrobial genomics · 2026Article
- Changing Clinical Spectrum of Invasive Meningococcal Disease in France (2014-2025): Impact of Age and Meningococcal Lineage on Atypical Presentations.Microorganisms · 2026Article
- Rapid and recent evolution ofMicrobial genomics · 2026Article
- Meningococcal carriage and transmission dynamics in college students in Louisville, Kentucky.PloS one · 2026Article
- The Return of MenW: Religious Mass Gatherings as Global Catalysts for Meningococcal Spread.Journal of epidemiology and global health · 2025Article
- Impact of host factors and invasive meningococci on bacterial adhesion, proliferation, primary nasal epithelial barrier function, and immune response.Microbiology spectrum · 2025Article
- Genomic analysis ofEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025Article
- Geographical and temporal variations of serogroups and clonal types ofJournal of medical microbiology · 2025Article
- Genomic Diversity and Antimicrobial Susceptibility of Invasive Neisseria meningitidis in South Africa, 2016-2021.The Journal of infectious diseases · 2024Article
- Article
- Global Epidemiology of Meningococcal Disease-Causing Serogroups Before and After the COVID-19 Pandemic: A Narrative Review.Infectious diseases and therapy · 2024Review
- Epidemiology and genetic diversity of invasive Neisseria meningitidis strains circulating in Portugal from 2003 to 2020.International microbiology : the official journal of the Spanish Society for Microbiology · 2024Article
- A speed limit on serial strain replacement from original antigenic sin.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Genomic Surveillance of Invasive Meningococcal Disease During a National MenW Outbreak in Australia, 2017-2018.Open forum infectious diseases · 2024Article
- A speed limit on serial strain replacement from original antigenic sin.bioRxiv : the preprint server for biology · 2024Article
- Classification ofiScience · 2024Article
- Obstetric and Neonatal Invasive Meningococcal Disease Caused by Neisseria meningitidis Serogroup W, Western Australia, Australia.Emerging infectious diseases · 2024Article
- Impact of Meningococcal ACWY Vaccination Program during 2017-18 Epidemic, Western Australia, Australia.Emerging infectious diseases · 2024Article
58 more citing papers are in PubMed but not listed here.
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Authors and funding
15 authors at 10 institutions in 8 countries.
Funding
Abstract
objectivesNeisseria meningitidis is a leading cause of meningitis and septicaemia. The hyperinvasive ST-11 clonal complex (cc11) caused serogroup C (MenC) outbreaks in the US military in the 1960s and UK universities in the 1990s, a global Hajj-associated serogroup W (MenW) outbreak in 2000-2001, and subsequent MenW epidemics in sub-Saharan Africa. More recently, endemic MenW disease has expanded in South Africa, South America and the UK, and MenC cases have been reported among European and North American men who have sex with men (MSM). Routine typing schemes poorly resolve cc11 so we established the population structure at genomic resolution.
methodsRepresentatives of these episodes and other geo-temporally diverse cc11 meningococci (n = 750) were compared across 1546 core genes and visualised on phylogenetic networks.
resultsMenW isolates were confined to a distal portion of one of two main lineages with MenB and MenC isolates interspersed elsewhere. An expanding South American/UK MenW strain was distinct from the 'Hajj outbreak' strain and a closely related endemic South African strain. Recent MenC isolates from MSM in France and the UK were closely related but distinct.
conclusionsHigh resolution 'genomic' multilocus sequence typing is necessary to resolve and monitor the spread of diverse cc11 lineages globally.
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