ArticleJournal of acquired immune deficiency syndromes (1999)2015
Intentional Medication Nonadherence Because of Interactive Toxicity Beliefs Among HIV-Positive Active Drug Users.
Article in Journal of acquired immune deficiency syndromes (1999), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- A conceptual model of alcohol use and adherence to antiretroviral therapy: systematic review and theoretical implications for mechanisms of action.Health psychology review · 2022Pooled it
- Effects of a person-centred, nurse-led follow-up programme on adherence to prescribed medication among patients surgically treated for intermittent claudication: randomized clinical trial.The British journal of surgery · 2022Trial
- Substance use interactive toxicity beliefs impede HIV pre-exposure prophylaxis use among men who have sex with men.Journal of behavioral medicine · 2026Article
- Article
- Intentional- but not Unintentional Medication Non-adherence was Related with Beliefs about Medicines Among a Multi-Ethnic Sample of People with HIV.AIDS and behavior · 2023Article
- Increasing emergency department admissions for chemsex-related intoxications in Barcelona, Spain, among people living with HIV: an observational study from 2018 to 2020.BMC public health · 2022Observational
- Substance Use-Related Intentional Nonadherence to Antiretroviral Therapy Among Young Adults Living with HIV.AIDS patient care and STDs · 2022Article
- Forgetting to take HIV antiretroviral therapy: a qualitative exploration of medication adherence in the third decade of the HIV epidemic in the United States.SAHARA J : journal of Social Aspects of HIV/AIDS Research Alliance · 2021Article
- 'Staying alive' with antiretroviral therapy: a grounded theory study of people living with HIV in Peru.BMJ global health · 2021Article
- Article
- Alcohol-related beliefs and non-adherence to antiretroviral therapy in Cape Town, South Africa.Journal of behavioral medicine · 2020Article
- Drug use and antiretroviral therapy (ART) interactions: a qualitative study to explore the knowledge, beliefs, adherence, and quality of life of people living with HIV taking ART and illicit drugs.AIDS research and therapy · 2020Article
- Follow-up after surgical treatment for intermittent claudication (FASTIC): a study protocol for a multicentre randomised controlled clinical trial.BMC nursing · 2020Article
- Relationship Stigma and HIV Risk Behavior Among Cisgender Men Partnered with Transgender Women: The Moderating Role of Sexual Identity.Archives of sexual behavior · 2020Article
- Alcohol-related intentional nonadherence to antiretroviral therapy among people living with HIV, Cape Town, South Africa.AIDS care · 2019Article
- Substance Use Stigma and Antiretroviral Therapy Adherence Among a Drug-Using Population Living with HIV.AIDS patient care and STDs · 2019Article
- Perceived sensitivity to medicines, alcohol interactive toxicity beliefs, and medication adherence among people living with HIV who drink alcohol.Journal of behavioral medicine · 2019Article
- Ethnopharmacological Applications Targeting Alcohol Abuse: Overview and Outlook.Frontiers in pharmacology · 2019Review
- Persons living with HIV with advanced HIV disease: need for novel care models.Journal of the International AIDS Society · 2018Article
- Psychiatric Illness, Substance Use, and Viral Suppression Among HIV-Positive Men of Color Who Have Sex with Men in Los Angeles.AIDS and behavior · 2018Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDrug use poses significant challenges to medical management of HIV infection. Although most research has focused on the influence of intoxication on unintentional adherence to HIV treatment, drug use may also lead to intentional nonadherence, particularly when individuals believe that mixing medications with drugs is harmful. This study examined whether interactive toxicity beliefs predict nonadherence to antiretroviral therapy (ART) over a prospective period of adherence monitoring.
methodsMen and women living with HIV who screened positive for drug use and were being treated with ART (n = 530) completed computerized self-interviews and 3 prospective unannounced pill counts to measure ART adherence and provided urine specimens for drug screening and HIV viral load results from medical records.
resultsResults showed that 189 (35%) participants indicated that they intentionally miss their ART when they are using drugs. These participants also reported common beliefs regarding the perceived hazards of mixing HIV medications with alcohol and other drugs. Multivariable models controlled for demographic and health characteristics and frequency of alcohol use showed that intentional nonadherence predicted poorer ART adherence over the prospective month and also predicted poorer treatment outcomes as indexed by unsuppressed HIV viral load.
conclusionsThese findings extend previous research to show that interactive toxicity beliefs and intentional nonadherence play a significant role in medication nonadherence for a substantial number of people living with HIV and should be actively addressed in HIV clinical care.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.