Trial reportJournal of perinatology : official journal of the California Perinatal Association2015
Early versus delayed umbilical cord clamping in infants with congenital heart disease: a pilot, randomized, controlled trial.
Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Resuscitation of Infants With Congenital Diaphragmatic Hernia With an Intact Umbilical Cord
CORD-CHD: Clamp OR Delay Among Neonates With Congenital Heart Disease
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- 2025 Korean Guidelines for Cardiopulmonary Resuscitation: Part 9. Neonatal resuscitation.Clinical and experimental emergency medicine · 2026Guideline
- Physiological-Based Cord Clamping and Early Oxygenation in Newborns With Transposition of the Great Arteries: A Quality Improvement Study Protocol.CJC pediatric and congenital heart disease · 2026Article
- Comparison of the Effects of Early Versus Delayed Cord Clamping on Haemoglobin Levels in Neonates Delivered at Term.Cureus · 2024Article
- Call to action: prioritizing delivery room care for neonates with critical congenital heart disease.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- [Interpretation of 2023 American Heart Association and American Academy of Pediatrics focused update on neonatal resuscitation guidelines].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
- Maternal implications of placental transfusion.Seminars in perinatology · 2023Article
- What does the evidence tell us? Revisiting optimal cord management at the time of birth.European journal of pediatrics · 2022Review
- A review on development of placental transfusion in term and preterm infants.Frontiers in pediatrics · 2022Review
- Article
- Timing of umbilical cord clamping among infants with congenital heart disease.Progress in pediatric cardiology · 2020Article
- Early versus delayed umbilical cord clamping on maternal and neonatal outcomes.Archives of gynecology and obstetrics · 2019Review
- Italian Recommendations for Placental Transfusion Strategies.Frontiers in pediatrics · 2018Review
- Placental transfusion: a review.Journal of perinatology : official journal of the California Perinatal Association · 2017Review
- A quality improvement initiative for delayed umbilical cord clamping in very low-birthweight infants.BMC pediatrics · 2016Article
- Current umbilical cord clamping practices and attitudes of obstetricians and midwives toward delayed cord clamping in Saudi Arabia.Annals of Saudi medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveDelayed umbilical cord clamping (DCC) at birth may provide a better neonatal health status than early umbilical cord clamping (ECC). However, the safety and feasibility of DCC in infants with congenital heart disease (CHD) have not been tested. This was a pilot, randomized, controlled trial to establish the safety and feasibility of DCC in neonates with CHD. STUDY
designPregnant women admitted >37 weeks gestational age with prenatal diagnosis of critical CHD were enrolled and randomized to ECC or DCC. For ECC, the umbilical cord was clamped <10 s after birth; for DCC, the cord was clamped ~120 s after delivery.
resultsThirty infants were randomized at birth. No differences between the DCC and ECC groups were observed in gestational age at birth or time of surgery. No differences were observed across all safety measures, although a trend for higher peak serum bilirubin levels (9.2±2.2 vs 7.3±3.2 mg dl(-1), P=0.08) in the DCC group than in the ECC group was noted. Although similar at later time points, hematocrits were higher in the DCC than in the ECC infants during the first 72 h of life. The proportion of infants not receiving blood transfusions throughout hospitalization was higher in the DCC than in the ECC infants (43 vs 7%, log-rank test P=0.02).
conclusionDCC in infants with critical CHD appears both safe and feasible, with fewer infants exposed to red blood cell transfusions than with ECC. A more comprehensive appraisal of this practice is warranted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.