Evidence map›Paper›PMID 26226243›Full record

SynthesisJournal of perinatology : official journal of the California Perinatal Association2015

Tranexamic acid and blood loss during and after cesarean section: a meta-analysis.

H-Y Wang, S-K Hong, Y Duan, H-M Yin

5 registry-linked trialsOpen access · bronzeAbstract readMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in Journal of perinatology : official journal of the California Perinatal Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02739815 phase4completednot on this mapstarted 2016, after this paper: background citation

Comparative Study For Role Of Different Prophylactic Doses Of Intravenous Tranexamic Acid In Reducing Blood Loss At Caesarean Section: A Randomised Controlled Trial

TypeinterventionalSponsorTalkha Central HospitalRan2016 to 2016Enrolled200ConditionsHemorrhage of Cesarean Section and/or Perineal Wound, Postpartum HemorrhageArmsNormal Saline containing a prophylactic Antibiotic 1 g, Tranexamic Acid
NCT02780245 phase4completednot on this mapstarted 2016, after this paper: background citation

Tranexamic Acid Versus Novel Uterine Cooling Technique in Reducing Blood Loss and Incidence of Postpartum Hemorrhage at Caesarean Section

TypeinterventionalSponsorTalkha Central HospitalRan2016 to 2016Enrolled100ConditionsHemorrhage of Cesarean Section and/or Perineal Wound, Postpartum Hemorrhage, Uterine AtonyArmsTranexamic Acid, Intraoperative Uterine Cooling
NCT03326596 phase4withdrawnnot on this mapstarted 2018, after this paper: background citation

Prevention of Postpartum Hemorrhage With Tranexamic Acid (TXA)

TypeinterventionalSponsorUnited States Naval Medical Center, San DiegoRan2018 to 2019Enrolled0ConditionsPostpartum HemorrhageArmsTranexamic Acid 1000 mg/10ml normal saline infusion
NCT03364491 phase3completednot on this mapstarted 2018, after this paper: background citation

Tranexamic Acid for the Prevention of Obstetrical Hemorrhage After Cesarean Delivery: A Randomized Controlled Trial

TypeinterventionalSponsorThe George Washington University Biostatistics CenterRan2018 to 2021Enrolled11,000ConditionsObstetrical Complications, Hemorrhage, Labor and DeliveryArmsTranexamic Acid, Placebo
NCT03793153 nacompletednot on this mapstarted 2018, after this paper: background citation

A Novel Technique Of Uterine Cooling During Repeated Cesarean Section For Reducing Blood Loss

TypeinterventionalSponsorAl-Azhar UniversityRan2018 to 2019Enrolled99ConditionsCesarean Section Complications, Intrapartum Hemorrhage, Postpartum Hemorrhage, Atony, UterineArmsUterine Cooling Technique
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Efficacy of tranexamic acid application in gynecology and obstetrics procedures: a umbrella review of systematic reviews of randomized trials.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2025
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

H-Y WangDepartment of Obstetrics and Gynecology, Shengli Oilfield Central Hospital, Binzhou Medical University, Dongying, China.
S-K HongDepartment of Obstetrics and Gynecology, Shengli Oilfield Central Hospital, Binzhou Medical University, Dongying, China.
Y DuanDepartment of Obstetrics and Gynecology, Shengli Oilfield Central Hospital, Binzhou Medical University, Dongying, China.
H-M YinDepartment of Obstetrics and Gynecology, Shengli Oilfield Central Hospital, Binzhou Medical University, Dongying, China.
Shengli Oilfield Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveA meta-analysis of randomized controlled trials (RCTs) was conducted to evaluate whether tranexamic acid (TXA) could significantly reduce blood loss during and after cesarean section (CS) when compared with no TXA. STUDY

designMEDLINE (PubMed), EMBASE, Cochrane Central Register of Controlled Trials and Web of Science were searched to identify RCTs that compared intravenous TXA with no TXA before CS for blood loss. The related data were extracted by two independent authors. The fixed or random-effect methods were used to combine data.

resultEleven RCTs were included in this analysis with a total of 1276 women in TXA group and 1255 in no TXA (control) group. Total blood loss during and after CS was significantly less in TXA group than in control group (mean difference (MD) -141.61 ml, 95% confidence interval (CI) -207.09 to -76.14, P<0.01). There was a significant reduction in intraoperative and postpartum blood loss in TXA group as compared with control group (MD -143.36 ml, 95% CI -220.38 to -66.35, P<0.01; and MD -38.20 ml, 95% CI -59.27 to -17.12, P<0.01, respectively). Declines in hemoglobin and hematocrit values after CS were both significantly less in TXA group than in control group. The difference of postpartum hemorrhage rate was statistically significant between groups (risk ratio (RR) 0.57, 95% CI 0.37 to 0.89, P=0.01). The need for blood transfusion was significantly less in TXA group than control group (RR 0.23, 95% CI 0.10 to 0.57, P<0.01).

conclusionOur results demonstrate that TXA offers an advantage over no TXA in reducing blood loss during and after CS.

Indexed as

Antifibrinolytic AgentsBlood Loss, SurgicalBlood TransfusionBlood VolumeCesarean SectionFemaleHumansIntraoperative ComplicationsPostoperative ComplicationsPregnancyPublication BiasRandomized Controlled Trials as TopicTranexamic AcidAntifibrinolytic AgentsTranexamic Acid

Identifiers

PMID26226243
OpenAlexW957262471

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.