ArticleJournal of perinatology : official journal of the California Perinatal Association2015
Maternal/neonatal vitamin D deficiency: a risk factor for bronchopulmonary dysplasia in preterms?
Article in Journal of perinatology : official journal of the California Perinatal Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03087149 (Supplementation of Vitamin D in Preterm Infants- Monitored Therapy vs Standard Therapy. A Randomized Controlled Trial), which is not on this map. Cited by 32 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Supplementation of Vitamin D in Preterm Infants- Monitored Therapy vs Standard Therapy. A Randomized Controlled Trial
Who cites it
32 citing papers in PubMed, 4 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Short-term and long-term effects of vitamin D supplementation for preterm infants: a systematic review and meta-analysis.Journal of perinatology : official journal of the California Perinatal Association · 2026Pooled it
- A systematic review and meta-analysis of Vitamin D status and clinical outcomes in critically ill neonates.Frontiers in nutrition · 2026Pooled it
- Association of Maternal Hypertensive Disorders During Pregnancy With Severe Bronchopulmonary Dysplasia: A Systematic Review and Meta-Analysis.Journal of Korean medical science · 2022Pooled it
- Association between vitamin D level and bronchopulmonary dysplasia: A systematic review and meta-analysis.PloS one · 2020Pooled it
- The Impact of Baseline 25-Hydroxyvitamin D Level and Gestational Age on Prenatal Vitamin D Supplementation to Prevent Offspring Asthma or Recurrent Wheezing.The American journal of clinical nutrition · 2023Trial
- A Comparison of 3 Vitamin D Dosing Regimens in Extremely Preterm Infants: A Randomized Controlled Trial.The Journal of pediatrics · 2016Trial
- Vitamin D Supplementation During Pregnancy and Maternal and Neonatal Vitamin D Status at ≤32 Weeks Gestation: Romanian Prospective Observational Cohort Study.Children (Basel, Switzerland) · 2025Article
- Nonlinear relationship between vitamin D status on admission and bronchopulmonary dysplasia in preterm infants.Pediatric research · 2025Article
- Vitamin D: What We Know and What We Still Do Not Know About Vitamin D in Preterm Infants-A Literature Review.Children (Basel, Switzerland) · 2025Review
- Research progress on pathophysiologic mechanisms, clinical treatment and predictive biomarkers in bronchopulmonary dysplasia: from the perspective of oxidative stress.Frontiers in pediatrics · 2024Review
- The role of vitamin D receptor gene polymorphism in the development of necrotizing enterocolitis.Pediatric research · 2023Article
- Vitamin d deficiency with high parathyroid hormone levels is related to late onset SEPSIS among preterm infants.BMC pregnancy and childbirth · 2023Article
- Association between vitamin D deficiency at one month of age and bronchopulmonary dysplasia.Medicine · 2021Observational
- The Effect of Vitamin D Prophylaxis on 25-OH Vitamin D Levels in Children.Turkish archives of pediatrics · 2021Article
- Relationship between bronchopulmonary dysplasia, long-term lung function, and vitamin D level at birth in preterm infants.Translational pediatrics · 2021Article
- [A comparative analysis of the efficacy of two vitamin D supplementation regimens in preterm infants: a prospective randomized controlled study].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2020Article
- Vitamin D deficiency and its effect on respiratory distress syndrome in premature infants: results from a prospective study in a tertiary care centre.African health sciences · 2020Article
- Nutrients and Microbiota in Lung Diseases of Prematurity: The Placenta-Gut-Lung Triangle.Nutrients · 2020Review
- [Protective effect of vitamin D against hyperoxia-induced bronchopulmonary dysplasia in newborn mice].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2019Article
- Association between vitamin D level at birth and respiratory morbidities in very-low-birth-weight infants.Korean journal of pediatrics · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe objective of this study was to investigate the possible association between maternal/neonatal 25-hydroxy vitamin D (25-OHD) levels and development of bronchopulmonary dysplasia. STUDY
designOne hundred and thirty-two preterm infants ⩽32 weeks of gestation who were diagnosed with respiratory distress syndrome were enrolled. 25-OHD levels were determined in maternal/neonatal blood samples that were obtained at the time of admission to the neonatal intensive care unit.
resultA total of 100 infants were included and 31 (31%) developed bronchopulmonary dysplasia (BPD). Both maternal and neonatal 25-OHD levels in the BPD group were significantly lower compared with those in the no-BPD group (P=0.0001). A positive correlation was detected between maternal and neonatal 25-OHD levels. All of the infants with BPD had a 25-OHD level <10 ng ml(-1), which represented severe deficiency. Univariate logistic regression analysis revealed that maternal/neonatal vitamin D levels were a significant predictor of BPD (odds ratio (OR): 0.76 and 0.61, respectively, P<0.001).
conclusionWe demonstrated for the first time that lower maternal and neonatal vitamin 25-OHD levels were associated with BPD development in preterm infants. However, further studies with larger sample sizes are needed to delineate the possible link between vitamin D deficiency and BPD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.