ArticleHeart rhythm2016
A swine model of infarct-related reentrant ventricular tachycardia: Electroanatomic, magnetic resonance, and histopathological characterization.
Article in Heart rhythm, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04512911 (Endocardial-Epicardial Radiofrequency Ablation of Ventricular Tachycardia in Patients With Ischemic Cardiomyopathy), which is not on this map. Cited by 53 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Endocardial-Epicardial Radiofrequency Ablation of Ventricular Tachycardia in Patients With Ischemic Cardiomyopathy
Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it, 105 citations in OpenAlex.
- First-line ablation of ventricular tachycardia in ischemic cardiomyopathy: stratification of outcomes by left ventricular function.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2021Pooled it
- A coronary anatomy-guided myocardial infarction strategy for optimizing survival and ventricular tachycardia inducibility in a porcine model.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026Article
- STAR Locally Prolongs Effective Refractory Period and Increases Ventricular Tachycardia Cycle Length Without Short-Term Scar Formation or Functional Decline: Insights From a Translational Porcine Model Study.Circulation. Arrhythmia and electrophysiology · 2025Article
- Intracoronary-Cardiosphere-Derived Cell Secretome Therapy: Effects on Ventricular Tachycardia Inducibility and Cardiac Function in a Swine Model.Biomedicines · 2025Article
- Cardiorespiratory-gated cardiac proton radiotherapy using a novel ultrasound guidance system.Clinical and translational radiation oncology · 2025Article
- Canine Model of Ischemia-Induced Ventricular Tachycardia.The Journal of surgical research · 2024Article
- Article
- Catheter ablation of ventricular tachycardia: strategies to improve outcomes.Frontiers in cardiovascular medicine · 2023Review
- The Impact of a Modified Anaesthetic Protocol on Animal Survival and the Characteristics of Ventricular Arrhythmias in the Course of Acute Myocardial Infarction in a Domestic Pig Model.Journal of veterinary research · 2022Article
- A novel ECG finding in patients with epicardial infarct-associated ventricular tachycardia: a case series.Herzschrittmachertherapie & Elektrophysiologie · 2022Article
- Effect of scar and pacing location on repolarization in a porcine myocardial infarction model.Heart rhythm O2 · 2022Article
- Magnetic susceptibility and R2* of myocardial reperfusion injury at 3T and 7T.Magnetic resonance in medicine · 2022Article
- Metabolic Scar Assessment withJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021Article
- Flecainide in Ventricular Arrhythmias: From Old Myths to New Perspectives.Journal of clinical medicine · 2021Review
- Epicardial-Endocardial Reentry in Ischemic Cardiomyopathy.The Journal of innovations in cardiac rhythm management · 2021Article
- Impact of revascularization in patients with post-infarction left ventricular aneurysm and ventricular tachyarrhythmia.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2021Article
- Article
- Contrast-free high-resolution 3D magnetization transfer imaging for simultaneous myocardial scar and cardiac vein visualization.Magma (New York, N.Y.) · 2020Article
- Iron imaging in myocardial infarction reperfusion injury.Nature communications · 2020Article
- Surgical Endoepicardial Linear Ablation for Ventricular Tachycardia With Postinfarction Left Ventricular Aneurysm.Texas Heart Institute journal · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundHuman ventricular tachycardia (VT) after myocardial infarction usually occurs because of subendocardial reentrant circuits originating in scar tissue that borders surviving myocardial bundles. Several preclinical large animal models have been used to further study postinfarct reentrant VT, but with varied experimental methodologies and limited evaluation of the underlying substrate or induced arrhythmia mechanism.
objectiveWe aimed to develop and characterize a swine model of scar-related reentrant VT.
methodsThirty-five Yorkshire swine underwent 180-minute occlusion of the left anterior descending coronary artery. Thirty-one animals (89%) survived the 6-8-week survival period. These animals underwent cardiac magnetic resonance imaging followed by electrophysiology study, detailed electroanatomic mapping, and histopathological analysis.
resultsLeft ventricular (LV) ejection fraction measured using CMR imaging was 36% ± 6.6% with anteroseptal wall motion abnormality and late gadolinium enhancement across 12.5% ± 4.1% of the LV surface area. Low voltage measured using endocardial electroanatomic mapping encompassed 11.1% ± 3.5% of the LV surface area (bipolar voltage ≤1.5 mV) with anterior, anteroseptal, and anterolateral involvement. Reentrant circuits mapped were largely determined by functional rather than fix anatomical barriers, consistent with "pseudo-block" due to anisotropic conduction. Sustained monomorphic VT was induced in 28 of 31 swine (90%) (67 VTs; 2.4 ± 1.1; range 1-4) and characterized as reentry. VT circuits were subendocardial, with an arrhythmogenic substrate characterized by transmural anterior scar with varying degrees of fibrosis and myocardial fiber disarray on the septal and lateral borders.
conclusionThis is a well-characterized swine model of scar-related subendocardial reentrant VT. This model can serve as the basis for further investigation in the physiology and therapeutics of humanlike postinfarction reentrant VT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.