ArticlePloS one2015
Biocompatibility of Polypyrrole with Human Primary Osteoblasts and the Effect of Dopants.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 73 citations in OpenAlex.
- Ultrasensitive Electrochemical Detection ofBiosensors · 2024Article
- Chlorpromazine-Polypyrrole Drug Delivery System Tailored for Neurological Application.Molecules (Basel, Switzerland) · 2024Article
- Biomimetic platelet-camouflaged drug-loaded polypyrrole for the precise targeted antithrombotic therapy.Journal of nanobiotechnology · 2023Article
- Aqueous Processable One-Dimensional Polypyrrole Nanostructured by Lignocellulose Nanofibril: A Conductive Interfacing Biomaterial.Biomacromolecules · 2023Article
- Design of Pyrrole-Based Gate-Controlled Molecular Junctions Optimized for Single-Molecule Aflatoxin B1 Detection.Sensors (Basel, Switzerland) · 2023Article
- Electrically controlled mRNA delivery using a polypyrrole-graphene oxide hybrid film to promote osteogenic differentiation of human mesenchymal stem cells.Nano research · 2022Article
- Innovative functional polymerization of pyrrole-N-propionic acid onto WSScientific reports · 2021Article
- Safety Assessment of Polypyrrole Nanoparticles and Spray-Coated Textiles.Nanomaterials (Basel, Switzerland) · 2021Article
- Soft Template Electropolymerization of Polypyrrole for Improved pH-Induced Drug Delivery.International journal of molecular sciences · 2020Article
- Article
- Conductive polymers to modulate the post-stroke neural environment.Brain research bulletin · 2019Review
- Article
- Gold Nanoparticles for Photothermal Cancer Therapy.Frontiers in chemistry · 2019Review
- Review
- [Preparation and biocompatibility of nano polypyrrole/chitin composite membrane].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2018Article
- A Gelatin Hydrogel-Containing Nano-Organic PEI⁻Ppy with a Photothermal Responsive Effect for Tissue Engineering Applications.Molecules (Basel, Switzerland) · 2018Article
- Recent Advances on Polypyrrole Electroactuators.Polymers · 2017Review
- Emerging Multifunctional NIR Photothermal Therapy Systems Based on Polypyrrole Nanoparticles.Polymers · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polypyrrole (PPy) is a conducting polymer that enables controlled drug release upon electrical stimulation. We characterized the biocompatibility of PPy with human primary osteoblasts, and the effect of dopants. We investigated the biocompatibility of PPy comprising various dopants, i.e. p-toluene sulfonate (PPy-pTS), chondroitin sulfate (PPy-CS), or dodecylbenzenesulfonate (PPy-DBS), with human primary osteoblasts. PPy-DBS showed the roughest appearance of all surfaces tested, and its wettability was similar to the gold-coated control. The average number of attached cells was 45% higher on PPy-DBS than on PPy-CS or PPy-pTS, although gene expression of the proliferation marker Ki-67 was similar in osteoblasts on all surfaces tested. Osteoblasts seeded on PPy-DBS or gold showed similar vinculin attachment points, vinculin area per cell area, actin filament structure, and Feret's diameter, while cells seeded on PPY-CS or PPY-pTS showed disturbed focal adhesions and were enlarged with disorganized actin filaments. Osteoblasts grown on PPy-DBS or gold showed enhanced alkaline phosphatase activity and osteocalcin gene expression, but reduced osteopontin gene expression compared to cells grown on PPy-pTS and PPy-CS. In conclusion, PPy doped with DBS showed excellent biocompatibility, which resulted in maintaining focal adhesions, cell morphology, cell number, alkaline phosphatase activity, and osteocalcin gene expression. Taken together, conducting polymers doped with DBS are well tolerated by osteoblasts. Our results could provide a basis for the development of novel orthopedic or dental implants with controlled release of antibiotics and pharmaceutics that fight infections or focally enhance bone formation in a tightly controlled manner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.