ArticleThe Journal of organic chemistry2015
Copper-Catalyzed Synthesis of Trifluoroethylarenes from Benzylic Bromodifluoroacetates.
Article in The Journal of organic chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Electricity-Controlled Divergent Synthesis of CFJACS Au · 2026Article
- Palladium-Catalyzed Decarbonylative C-H Difluoromethylation of Azoles.Organic letters · 2025Article
- Palladium-Catalyzed Decarbonylative Coupling of (Hetero)Aryl Boronate Esters with Difluorobenzyl Glutarimides.Organic letters · 2023Article
- Decarbonylative Fluoroalkylation at Palladium(II): From Fundamental Organometallic Studies to Catalysis.Journal of the American Chemical Society · 2021Article
- Interrupting the Barton-McCombie Reaction: Aqueous Deoxygenative Trifluoromethylation ofOrganic letters · 2021Article
- Metallaphotoredox Perfluoroalkylation of Organobromides.Journal of the American Chemical Society · 2020Article
- Nickel-Catalyzed Decarbonylative Synthesis of Fluoroalkyl Thioethers.ACS catalysis · 2020Article
- Copper-Catalyzed Trifluoromethylation of Alkyl Bromides.Journal of the American Chemical Society · 2019Article
- Catalytic One-Step Deoxytrifluoromethylation of Alcohols.The Journal of organic chemistry · 2019Article
- Aqueous Benzylic C-H Trifluoromethylation for Late-Stage Functionalization.Journal of the American Chemical Society · 2018Article
- Metal-catalyzed Decarboxylative Fluoroalkylation Reactions.Synlett : accounts and rapid communications in synthetic organic chemistry · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Trifluoroethylarenes are found in a variety of biologically active molecules, and strategies for accessing this substructure are important for developing therapeutic candidates and biological probes. Trifluoroethylarenes can be directly accessed via nucleophilic trifluoromethylation of benzylic electrophiles; however, current catalytic methods do not effectively transform electron-deficient substrates and heterocycles. To address this gap, we report a Cu-catalyzed decarboxylative trifluoromethylation of benzylic bromodifluoroacetates. To account for the tolerance of sensitive functional groups, we propose an inner-sphere mechanism of decarboxylation.
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