ArticleRedox biology2015
Singlet oxygen treatment of tumor cells triggers extracellular singlet oxygen generation, catalase inactivation and reactivation of intercellular apoptosis-inducing signaling.
Article in Redox biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 95 citations in OpenAlex.
- Assessing antitumor effects of plasma-activated phosphate buffered saline in breast cancer cell 2D and 3D models.Scientific reports · 2026Article
- Catalase: The golden key to regulate oxidative stress in breast cancer.World journal of clinical oncology · 2025Review
- Alkyl-π Liquids as Condensed-State Singlet Oxygen Photosensitizers.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Photodynamic therapy as a strategic ally in radiotherapy for triple-negative breast cancer: the importance of treatment order.Breast cancer research and treatment · 2025Article
- Cholesterol inhibits oxygen permeation through biological membranes: mechanism against double-bond peroxidation.RSC advances · 2024Article
- Generation of singlet oxygen inside living cells: correlation between phosphorescence decay lifetime, localization and outcome of photodynamic action.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2024Article
- Nanomaterials-Induced Redox Imbalance: Challenged and Opportunities for Nanomaterials in Cancer Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Antioxidant Enzymes in Cancer Cells: Their Role in Photodynamic Therapy Resistance and Potential as Targets for Improved Treatment Outcomes.International journal of molecular sciences · 2024Review
- Cellular Mechanisms of Singlet Oxygen in Photodynamic Therapy.International journal of molecular sciences · 2023Review
- Development of a modular photoreactor for the upscaling of continuous flow photochemistry.Reaction chemistry & engineering · 2022Article
- Recent Insights into NIR-Light-Responsive Materials for Photothermal Cell Treatments.Nanomaterials (Basel, Switzerland) · 2022Review
- Role of photobleaching process of indocyanine green for killing neuroblastoma cells.Biochemical and biophysical research communications · 2022Article
- Singlet Oxygen, Photodynamic Therapy, and Mechanisms of Cancer Cell Death.Journal of oncology · 2022Review
- Strategies for Improving Photodynamic Therapy Through Pharmacological Modulation of the Immediate Early Stress Response.Methods in molecular biology (Clifton, N.J.) · 2022Review
- Inhibition of Membrane-Associated Catalase, Extracellular ROS/RNS Signaling and Aquaporin/HAntioxidants (Basel, Switzerland) · 2021Article
- Selective Apoptotic Effect of Plasma Activated Liquids on Human Cancer Cell Lines.Molecules (Basel, Switzerland) · 2021Article
- Comprehensive Review of Methodology to Detect Reactive Oxygen Species (ROS) in Mammalian Species and Establish Its Relationship with Antioxidants and Cancer.Antioxidants (Basel, Switzerland) · 2021Review
- Oxidative stress concept updated: Definitions, classifications, and regulatory pathways implicated.EXCLI journal · 2021Review
- Article
- Targeting the Redox Landscape in Cancer Therapy.Cancers · 2020Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracellular singlet oxygen generation in photofrin-loaded cells caused cell death without discrimination between nonmalignant and malignant cells. In contrast, extracellular singlet oxygen generation caused apoptosis induction selectively in tumor cells through singlet oxygen-mediated inactivation of tumor cell protective catalase and subsequent reactivation of intercellular ROS-mediated apoptosis signaling through the HOCl and the NO/peroxynitrite signaling pathway. Singlet oxygen generation by extracellular photofrin alone was, however, not sufficient for optimal direct inactivation of catalase, but needed to trigger the generation of cell-derived extracellular singlet oxygen through the interaction between H2O2 and peroxynitrite. Thereby, formation of peroxynitrous acid, generation of hydroxyl radicals and formation of perhydroxyl radicals (HO2(.)) through hydroxyl radical/H2O2 interaction seemed to be required as intermediate steps. This amplificatory mechanism led to the formation of singlet oxygen at a sufficiently high concentration for optimal inactivation of membrane-associated catalase. At low initial concentrations of singlet oxygen, an additional amplification step needed to be activated. It depended on singlet oxygen-dependent activation of the FAS receptor and caspase-8, followed by caspase-8-mediated enhancement of NOX activity. The biochemical mechanisms described here might be considered as promising principle for the development of novel approaches in tumor therapy that specifically direct membrane-associated catalase of tumor cells and thus utilize tumor cell-specific apoptosis-inducing ROS signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.