Evidence map›Paper›PMID 26225487›Full record

ArticleChest2016

Longitudinal Effect of CPAP on BP in Resistant and Nonresistant Hypertension in a Large Clinic-Based Cohort.

Harneet K Walia, Sandra D Griffith, Nancy Foldvary-Schaefer, George Thomas, Emmanuel L Bravo, Douglas E Moul, Reena Mehra

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chest, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 26 citations in OpenAlex.

  1. Socioeconomic status impacts blood pressure response to positive airway pressure treatment.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022
    Trial
  2. Article
  3. Article
  4. International Consensus Statement on Obstructive Sleep Apnea.International forum of allergy & rhinology · 2023
    Review
  5. Article
  6. Review
  7. Review
  8. Apneic Sleep, Insufficient Sleep, and Hypertension.Hypertension (Dallas, Tex. : 1979) · 2019
    Review
  9. Sleep Apnea Is a Risk Factor for Stroke and Vascular Dementia.Current neurology and neuroscience reports · 2018
    Review
  10. Sleep apnoea and stroke.Stroke and vascular neurology · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Harneet K WaliaSleep Disorders Center, Neurological Institute, Cleveland Clinic, Cleveland, OH. Electronic address: waliah@ccf.org.
Sandra D GriffithDepartment of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH.
Nancy Foldvary-SchaeferSleep Disorders Center, Neurological Institute, Cleveland Clinic, Cleveland, OH.
George ThomasDepartment of Nephrology and Hypertension, Cleveland Clinic, Cleveland, OH.
Emmanuel L BravoDepartment of Nephrology and Hypertension, Cleveland Clinic, Cleveland, OH.
Douglas E MoulSleep Disorders Center, Neurological Institute, Cleveland Clinic, Cleveland, OH.
Reena MehraSleep Disorders Center, Neurological Institute, Cleveland Clinic, Cleveland, OH.
Cleveland Clinic · US

Funding

Elucidation of the Influence of Sleep Apnea on Risk of Atrial FibrillationR01HL109493 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI MEHRA, REENA · 2011 to 2015
$3.7M
Sleep-Related Respiratory and Electrophysiological Atrial Fibrillation Predictor R21HL108226 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI MEHRA, REENA · 2012 to 2013
$515k
NHLBI NIH HHS R01 HL109493NHLBI NIH HHS R01HL109493NHLBI NIH HHS R21 HL108226NHLBI NIH HHS R21HL108226
6 · The paper itself

Abstract

backgroundClinic-based effectiveness studies of sleep-disordered breathing (SDB) treatment in reducing BP in resistant hypertension (RHTN) vs non-RHTN are sparse. We hypothesize that CPAP use in SDB reduces BP significantly in RHTN and non-RHTN in a large clinic-based cohort.

methodsElectronic medical records were reviewed in patients with SDB and comorbid RHTN and non-RHTN for CPAP therapy initiation (baseline) and subsequent visits. We estimated generalizable BP changes from multivariable mixed-effects linear models for systolic BP (SBP), diastolic BP, and mean arterial pressure, adjusting for RHTN status, age, sex, race, BMI, cardiac history, and diabetes and repeated measure correlation.

resultsOf 894 patients, 130 (15%) had RHTN at baseline (age, 58 ± 12 years; 52% men; BMI, 36 ± 9 kg/m(2)). Patients with RHTN had significantly higher BP overall (P < .001), most notably for SBP (6.9 mm Hg; 95% CI, 3.84, 9.94). In the year following CPAP initiation, improvements in BP indexes did not generally differ based on RHTN status in which RHTN status was a fixed effect. However, there was a significant decrease in SBP (3.08 mm Hg; 95% CI, 1.79, 4.37), diastolic BP (2.28; 95% CI, 1.56, 3.00), and mean arterial pressure (2.54 mm Hg; 95% CI, 1.73, 3.36) in both groups.

conclusionsIn this clinic-based effectiveness study involving patients closely followed for BP control, a significant reduction of BP measures (strongest for SBP) was observed in response to CPAP which was similar in RHTN and non-RHTN groups thus informing expected clinical CPAP treatment response.

Indexed as

Arterial PressureAgedAmbulatory Care FacilitiesAntihypertensive AgentsBlood PressureCase-Control StudiesCohort StudiesComorbidityContinuous Positive Airway PressureFemaleHumansHypertensionLinear ModelsLongitudinal StudiesMaleMiddle AgedAntihypertensive Agentshypertensionsleep-disorderedsleep medicine

Identifiers

PMID26225487
PMCPMC4944790
OpenAlexW2293104279

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.