ArticleBiological psychology2015
Juvenile onset depression alters cardiac autonomic balance in response to psychological and physical challenges.
Article in Biological psychology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Atypical reactivity of heart rate variability to stress and depression across development: Systematic review of the literature and directions for future research.Clinical psychology review · 2016Pooled it
- Children's altruism following acute stress: The role of autonomic nervous system activity and social support.Developmental science · 2021Trial
- Stress reactivity of the autonomic nervous system in youth with and without major depressive disorder.European child & adolescent psychiatry · 2026Article
- Characterizing the Autonomic Correlates of Negative Emotion Differentiation: Bridging Laboratory and Daily Life Assessments.Psychophysiology · 2025Article
- Short-Term Blood Pressure Variability among Young Adults at High or Low Risk for Depression.Journal of clinical medicine · 2024Article
- The role of youths' cardiac autonomic balance and parental responses to youth emotion in vulnerability to borderline personality disorder development.Development and psychopathology · 2024Article
- Unveiling gender differences in psychophysiological dynamics: support for a two-dimensional autonomic space approach.Frontiers in human neuroscience · 2024Article
- Cardiac Autonomic Balance Is Altered during the Acute Stress Response in Adolescent Major Depression-Effect of Sex.Life (Basel, Switzerland) · 2023Article
- Rethinking the risk for depression using the RDoC: A psychophysiological perspective.Frontiers in psychology · 2023Review
- Youth coping and cardiac autonomic functioning: Implications for social and academic adjustment.Developmental psychobiology · 2022Article
- Investigating autonomic biomarkers of sensory processing patterns in young adults.The British journal of occupational therapy · 2022Article
- The impact of social disadvantage on autonomic physiology of latinx adolescents: The role of environmental risks.New directions for child and adolescent development · 2022Article
- Emotion context insensitivity in depression: Toward an integrated and contextualized approach.Psychophysiology · 2021Review
- A Close Examination of the Use of Systolic Time Intervals in the Calculation of Impedance Derived Cardiac Autonomic Balance and Regulation.Frontiers in neuroscience · 2021Article
- Cross system autonomic balance and regulation: Associations with depression and anxiety symptoms.Psychophysiology · 2020Article
- Associations of depression severity with heart rate and heart rate variability in young adults across normative and clinical populations.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2019Article
- Lower resting cardiac autonomic balance in young adults with current major depression.Psychophysiology · 2019Article
- Neuroimmune Interactions in Schizophrenia: Focus on Vagus Nerve Stimulation and Activation of the Alpha-7 Nicotinic Acetylcholine Receptor.Frontiers in immunology · 2017Review
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
Abstract
Cardiac autonomic balance (CAB) indexes the ratio of parasympathetic to sympathetic activation (Berntson, Norman, Hawkley, & Cacioppo, 2008), and is believed to reflect overall autonomic flexibility in the face of environmental challenges. However, CAB has not been examined in depression. We examined changes in CAB and other physiological variables in 179 youth with a history of juvenile onset depression (JOD) and 161 healthy controls, in response to two psychological (unsolvable puzzle, sad film) and two physical (handgrip, and forehead cold pressor) challenges. In repeated measures analyses, controls showed expected reductions in CAB for both the handgrip and unsolvable puzzle, reflecting a shift to sympathetic relative to parasympathetic activation. By contrast, JOD youth showed increased CAB from baseline for both tasks (p's<.05). No effects were found for the forehead cold pressor or sad film tasks, suggesting that CAB differences may arise under conditions requiring greater attentional control or sustained effort.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.