Evidence map›Paper›PMID 26225451›Full record

ArticleRadiology2015

Influence of Cardiac MR Imaging on DNA Double-Strand Breaks in Human Blood Lymphocytes.

Michael Brand, Stephan Ellmann, Matthias Sommer, Matthias S May, Achim Eller, Wolfgang Wuest, Christina Engert, Stephan Achenbach, Michael A Kuefner, Tobias Baeuerle and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Radiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Cardiac MR imaging genotoxicity?European heart journal · 2018
    Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Michael BrandFrom the Department of Radiology, University Hospital Erlangen-Nuremberg, Maximiliansplatz 1, D-91054 Erlangen, Germany (M.B., S.E., M.S., M.S.M., A.E., W.W., C.E., M.A.K., T.B., M.L., M.U.); and Department of Cardiology, University Hospital Erlangen-Nuremberg, Erlangen, Germany (S.A.).
Stephan EllmannFrom the Department of Radiology, University Hospital Erlangen-Nuremberg, Maximiliansplatz 1, D-91054 Erlangen, Germany (M.B., S.E., M.S., M.S.M., A.E., W.W., C.E., M.A.K., T.B., M.L., M.U.); and Department of Cardiology, University Hospital Erlangen-Nuremberg, Erlangen, Germany (S.A.).
Matthias SommerFrom the Department of Radiology, University Hospital Erlangen-Nuremberg, Maximiliansplatz 1, D-91054 Erlangen, Germany (M.B., S.E., M.S., M.S.M., A.E., W.W., C.E., M.A.K., T.B., M.L., M.U.); and Department of Cardiology, University Hospital Erlangen-Nuremberg, Erlangen, Germany (S.A.).
Matthias S MayFrom the Department of Radiology, University Hospital Erlangen-Nuremberg, Maximiliansplatz 1, D-91054 Erlangen, Germany (M.B., S.E., M.S., M.S.M., A.E., W.W., C.E., M.A.K., T.B., M.L., M.U.); and Department of Cardiology, University Hospital Erlangen-Nuremberg, Erlangen, Germany (S.A.).
Achim EllerFrom the Department of Radiology, University Hospital Erlangen-Nuremberg, Maximiliansplatz 1, D-91054 Erlangen, Germany (M.B., S.E., M.S., M.S.M., A.E., W.W., C.E., M.A.K., T.B., M.L., M.U.); and Department of Cardiology, University Hospital Erlangen-Nuremberg, Erlangen, Germany (S.A.).
Wolfgang WuestFrom the Department of Radiology, University Hospital Erlangen-Nuremberg, Maximiliansplatz 1, D-91054 Erlangen, Germany (M.B., S.E., M.S., M.S.M., A.E., W.W., C.E., M.A.K., T.B., M.L., M.U.); and Department of Cardiology, University Hospital Erlangen-Nuremberg, Erlangen, Germany (S.A.).
Christina EngertFrom the Department of Radiology, University Hospital Erlangen-Nuremberg, Maximiliansplatz 1, D-91054 Erlangen, Germany (M.B., S.E., M.S., M.S.M., A.E., W.W., C.E., M.A.K., T.B., M.L., M.U.); and Department of Cardiology, University Hospital Erlangen-Nuremberg, Erlangen, Germany (S.A.).
Stephan AchenbachFrom the Department of Radiology, University Hospital Erlangen-Nuremberg, Maximiliansplatz 1, D-91054 Erlangen, Germany (M.B., S.E., M.S., M.S.M., A.E., W.W., C.E., M.A.K., T.B., M.L., M.U.); and Department of Cardiology, University Hospital Erlangen-Nuremberg, Erlangen, Germany (S.A.).
Michael A KuefnerFrom the Department of Radiology, University Hospital Erlangen-Nuremberg, Maximiliansplatz 1, D-91054 Erlangen, Germany (M.B., S.E., M.S., M.S.M., A.E., W.W., C.E., M.A.K., T.B., M.L., M.U.); and Department of Cardiology, University Hospital Erlangen-Nuremberg, Erlangen, Germany (S.A.).
Tobias BaeuerleFrom the Department of Radiology, University Hospital Erlangen-Nuremberg, Maximiliansplatz 1, D-91054 Erlangen, Germany (M.B., S.E., M.S., M.S.M., A.E., W.W., C.E., M.A.K., T.B., M.L., M.U.); and Department of Cardiology, University Hospital Erlangen-Nuremberg, Erlangen, Germany (S.A.).
Michael LellFrom the Department of Radiology, University Hospital Erlangen-Nuremberg, Maximiliansplatz 1, D-91054 Erlangen, Germany (M.B., S.E., M.S., M.S.M., A.E., W.W., C.E., M.A.K., T.B., M.L., M.U.); and Department of Cardiology, University Hospital Erlangen-Nuremberg, Erlangen, Germany (S.A.).
Michael UderFrom the Department of Radiology, University Hospital Erlangen-Nuremberg, Maximiliansplatz 1, D-91054 Erlangen, Germany (M.B., S.E., M.S., M.S.M., A.E., W.W., C.E., M.A.K., T.B., M.L., M.U.); and Department of Cardiology, University Hospital Erlangen-Nuremberg, Erlangen, Germany (S.A.).
Universitätsklinikum Erlangen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the ability of magnetic resonance (MR) imaging to induce deoxyribonucleic acid (DNA) damage in patients who underwent cardiac MR imaging in daily routine by using γ-H2AX immunofluorescence microscopy. MATERIALS AND

methodsThis study complies with the Declaration of Helsinki and was performed according to local ethics committee approval. Informed patient consent was obtained. Blood samples from 45 patients (13 women, 32 men; mean age, 50.3 years [age range, 20-89 years]) were obtained before and after contrast agent-enhanced cardiac MR imaging. MR imaging-induced double-strand breaks (DSBs) were quantified in isolated blood lymphocytes by using immunofluorescence microscopy after staining the phosphorylated histone variant γ-H2AX. Twenty-nine patients were examined with a myocarditis protocol (group A), 10 patients with a stress-testing protocol (group B), and six patients with flow measurements and angiography (group C). Paired t test was performed to compare excess foci before and after MR imaging.

resultsThe mean baseline DSB level before MR imaging and 5 minutes after MR imaging was, respectively, 0.116 DSB per cell ± 0.019 (standard deviation) and 0.117 DSB per cell ± 0.019 (P = .71). There was also no significant difference in DSBs in these subgroups (group A: DSB per cell before and after MR imaging, respectively, 0.114 and 0.114, P = .91; group B: DSB per cell before and after MR imaging, respectively, 0.123 and 0.124, P = .78; group C: DSB per cell before and after MR imaging, respectively, 0.114 and 0.115, P = .36).

conclusionBy using γ-H2AX immunofluorescence microscopy, no DNA DSBs were detected after cardiac MR imaging.

Indexed as

DNA Breaks, Double-StrandedLymphocytesMagnetic Resonance ImagingAdultAgedAged, 80 and overContrast MediaFemaleHeart DiseasesHumansMaleMicroscopy, FluorescenceMiddle AgedContrast Media

Identifiers

PMID26225451
OpenAlexW1878294173

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.