ArticlePloS one2015
Local Activity and Causal Connectivity in Children with Benign Epilepsy with Centrotemporal Spikes.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Cortical Excitability, Synaptic Plasticity, and Cognition in Benign Epilepsy With Centrotemporal Spikes: A Pilot TMS-EMG-EEG Study.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2020Trial
- Functional connectivity in self-limited epilepsy with centrotemporal spikes increases with epilepsy duration and interictal spike exposure.Epilepsia · 2026Article
- Decreased thalamocortical connectivity in resolved Rolandic epilepsy.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023Article
- Disrupted functional connectivity patterns of the left inferior frontal gyrus subregions in benign childhood epilepsy with centrotemporal spikes.Translational pediatrics · 2022Article
- Reconfiguration of static and dynamic thalamo-cortical network functional connectivity of epileptic children with generalized tonic-clonic seizures.Frontiers in neuroscience · 2022Article
- Reliability and availability of granger causality density in localization of Rolandic focus in BECTS.Brain imaging and behavior · 2021Article
- Aberrant Dynamics of Regional Coherence Measured by Resting-State fMRI in Children With Benign Epilepsy With Centrotemporal Spikes (BECTS).Frontiers in neurology · 2021Article
- Altered Static and Dynamic Spontaneous Neural Activity in Drug-Naïve and Drug-Receiving Benign Childhood Epilepsy With Centrotemporal Spikes.Frontiers in human neuroscience · 2020Article
- The epileptic network and cognition: What functional connectivity is teaching us about the childhood epilepsies.Epilepsia · 2019Review
- BECTS Substate Classification by Granger Causality Density Based Support Vector Machine Model.Frontiers in neurology · 2019Article
- Functional and Structural Network Disorganizations in Typical Epilepsy With Centro-Temporal Spikes and Impact on Cognitive Neurodevelopment.Frontiers in neurology · 2019Review
- Mapping the Effect of Interictal Epileptic Activity Density During Wakefulness on Brain Functioning in Focal Childhood Epilepsies With Centrotemporal Spikes.Frontiers in neurology · 2019Article
- The focal alteration and causal connectivity in children with new-onset benign epilepsy with centrotemporal spikes.Scientific reports · 2018Article
- Structural Covariance Network of Cortical Gyrification in Benign Childhood Epilepsy with Centrotemporal Spikes.Frontiers in neurology · 2018Article
- Identifying neural drivers of benign childhood epilepsy with centrotemporal spikes.NeuroImage. Clinical · 2018Article
- Decreased functional connectivity within a language subnetwork in benign epilepsy with centrotemporal spikes.Epilepsia open · 2017Article
- Altered Default Mode Network on Resting-State fMRI in Children with Infantile Spasms.Frontiers in neurology · 2017Article
- Functional Connectome before and following Temporal Lobectomy in Mesial Temporal Lobe Epilepsy.Scientific reports · 2016Article
- New Insights into Signed Path Coefficient Granger Causality Analysis.Frontiers in neuroinformatics · 2016Article
- Learning Effective Connectivity Network Structure from fMRI Data Based on Artificial Immune Algorithm.PloS one · 2016Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the current study was to localize the epileptic focus and characterize its causal relation with other brain regions, to understand the cognitive deficits in children with benign childhood epilepsy with centrotemporal spikes (BECTS). Resting-state functional magnetic resonance imaging (fMRI) was performed in 37 children with BECTS and 25 children matched for age, sex and educational achievement. We identified the potential epileptogenic zone (EZ) by comparing the amplitude of low frequency fluctuation (ALFF) of spontaneous blood oxygenation level dependent fMRI signals between the groups. Granger causality analysis was applied to explore the causal effect between EZ and the whole brain. Compared with controls, children with BECTS had significantly increased ALFF in the right postcentral gyrus and bilateral calcarine, and decreased ALFF in the left anterior cingulate cortex, bilateral putaman/caudate, and left cerebellum. ALFF values in the putaman/caudate were positively correlated with verbal IQ scores in patients. The ALFF values in cerebellum and performance IQ scores were negatively correlated in patients. These results suggest that ALFF disturbances in the putaman/caudate and cerebellum play an important role in BECTS cognitive dysfunction. Compared with controls, the patients showed increased driving effect from the EZ to the right medial frontal cortex and posterior cingulate cortex and decreased causal effects from the EZ to left inferior frontal gyrus. The causal effect of the left inferior frontal gyrus negatively correlated with disease duration, which suggests a relation between the epileptiform activity and language impairment. All together, these findings provide additional insight into the neurophysiological mechanisms of epilepitogenisis and cognitive dysfunction associated with BECTS.
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