ReviewCPT: pharmacometrics & systems pharmacology2015
Bridging Systems Medicine and Patient Needs.
Review in CPT: pharmacometrics & systems pharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Empirical methods for the validation of time-to-event mathematical models taking into account uncertainty and variability: application to EGFR + lung adenocarcinoma.BMC bioinformatics · 2023Article
- Perspectives of (/memorandum for) systems thinking on COVID-19 pandemic and pathology.Journal of evaluation in clinical practice · 2023Article
- Modeling the disruption of respiratory disease clinical trials by non-pharmaceutical COVID-19 interventions.Nature communications · 2022Article
- Optimizing circadian drug infusion schedules towards personalized cancer chronotherapy.PLoS computational biology · 2020Article
- Applying systems biology to biomedical research and health care: a précising definition of systems medicine.BMC health services research · 2017Article
- Common Elements in Rare Kidney Diseases: Conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.Kidney international · 2017Article
- Systems Chronotherapeutics.Pharmacological reviews · 2017Review
- Reconciling evidence-based medicine and precision medicine in the era of big data: challenges and opportunities.Genome medicine · 2016Review
- Autologous Bone Marrow Transplantation in Multiple Sclerosis: Biomarker Relevance for Patient Recruitment and Follow up.Journal of clinical & cellular immunology · 2016Article
- The new holism: P4 systems medicine and the medicalization of health and life itself.Medicine, health care, and philosophy · 2016Article
- A Novel Method to Verify Multilevel Computational Models of Biological Systems Using Multiscale Spatio-Temporal Meta Model Checking.PloS one · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While there is widespread consensus on the need both to change the prevailing research and development (R&D) paradigm and provide the community with an efficient way to personalize medicine, ecosystem stakeholders grapple with divergent conceptions about which quantitative approach should be preferred. The primary purpose of this position paper is to contrast these approaches. The second objective is to introduce a framework to bridge simulation outputs and patient outcomes, thus empowering the implementation of systems medicine.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.