ArticleAJOB primary research2011
Participants' Perceptions of Deep Brain Stimulation Research for Treatment-Resistant Depression: Risks, Benefits, and Therapeutic Misconception.
Article in AJOB primary research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Barriers and facilitators to implementing deep brain stimulation for psychiatric disorders: a systematic review.Translational psychiatry · 2026Pooled it
- Views about neuromodulation interventions for depression by stakeholder group, treatment modality, and depression severity.Comprehensive psychiatry · 2023Trial
- Public Perceptions of Neurotechnologies Used to Target Mood, Memory, and Motor Symptoms.Device · 2025Article
- The influence of prior awareness on views about psychiatric electroceutical interventions among non-clinician stakeholders.Npj mental health research · 2023Article
- Article
- Influence of Dispositional Optimism on Ethically Salient Research Perspectives: A Pilot Study.Ethics & human research · 2022Article
- Factors Influencing Perceived Helpfulness and Participation in Innovative Research: A Pilot Study of Individuals with and without Mood Symptoms.Ethics & behavior · 2022Article
- Beyond the Cuckoo's Nest: Patient and Public Attitudes about Psychiatric Electroceutical Interventions.The Psychiatric quarterly · 2021Article
- Authentic Self and Last Resort: International Perceptions of Psychiatric Neurosurgery.Culture, medicine and psychiatry · 2021Article
- A qualitative study of key stakeholders' perceived risks and benefits of psychiatric electroceutical interventions.Health, risk & society · 2021Article
- DBS: a compelling example for ethical and legal reflection-a French perspective on ethical and legal concerns about DBS.Monash bioethics review · 2020Article
- Negative association of perceived risk and willingness to participate in innovative psychiatric research protocols.Journal of psychiatric research · 2020Article
- Patient's lived experience with DBS between medical research and care: some legal implications.Medicine, health care, and philosophy · 2019Article
- Informed Consent Decision-Making in Deep Brain Stimulation.Brain sciences · 2018Review
- The effect of depression on the decision to join a clinical trial.Journal of consulting and clinical psychology · 2017Article
- Deep brain stimulation for obsessive-compulsive disorder: Knowledge and concerns among psychiatrists, psychotherapists and patients.Surgical neurology international · 2017Article
- Autonomy in Depressive Patients Undergoing DBS-Treatment: Informed Consent, Freedom of Will and DBS' Potential to Restore It.Frontiers in integrative neuroscience · 2017Article
- The ethics of research on deep brain stimulation for depression: decisional capacity and therapeutic misconception.Annals of the New York Academy of Sciences · 2012Article
- An exploratory study of therapeutic misconception among incarcerated clinical trial participants.AJOB empirical bioethicsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundDeep brain stimulation (DBS) for treatment-resistant depression (TRD) is the focus of great interest and numerous studies. Given the state of this research, the risks of DBS, the uncertainty of direct benefits, and the potential for therapeutic misconception (TM), examination of research participants' perspectives is critical to addressing concerns about the adequacy of consent among people with TRD.
methodsAmong 31 participants considering DBS studies at two sites, self-report questionnaires were used to examine three dimensions of TM (eight true/false items). Additional Likert-scale items assessed perceptions of risks, potential benefits, and altruistic motivations.
resultsParticipants correctly identified the surgery itself as the riskiest study procedure, although only four participants rated the surgery as "high risk." Most participants rated the entire DBS study as "moderate" or lower risk. Participants rated the likelihood of others benefiting in the future more strongly than they did the likelihood of personal benefit. Participants held positive attitudes toward research, and were moderately altruistic. Nearly two-thirds of the 31 participants (64.5%) answered at least one of the true/false TM items incorrectly.
conclusionsIndividuals considering DBS studies for TRD demonstrated reasonable perceptions of risks and benefits, distinguished among procedural risks, and expressed hopes for personal benefit as well as altruism. Findings related to TM were mixed: Participants understood the experimental stage of DBS for depression and endorsed the possibility of no personal benefit, yet there was some evidence for TM. Although these findings are reassuring, investigators must nevertheless remain vigilant about identifying and addressing potential misconceptions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.