ArticleProteome science2015
iTRAQ-based proteomic profiling of Vibrio parahaemolyticus under various culture conditions.
Article in Proteome science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Shotgun proteomics for biomarker discovery in microbial pathogens and allergens in food: a review.Frontiers in bioengineering and biotechnology · 2026Review
- Cuminal InhibitsMicroorganisms · 2020Article
- Comparative Proteomics and Secretomics Revealed Virulence and Antibiotic Resistance-Associated Factors inFrontiers in microbiology · 2020Article
- Global Proteomic Analysis of the Resuscitation State ofFrontiers in microbiology · 2019Article
- Analysis of theJournal of extracellular vesicles · 2019Article
- A Damaged Oxidative Phosphorylation Mechanism Is Involved in the Antifungal Activity of Citral againstFrontiers in microbiology · 2018Article
- NMR-based metabolomics reveals the metabolite profiles of Vibrio parahaemolyticus under ferric iron stimulation.Journal of microbiology (Seoul, Korea) · 2017Article
- Quantitative proteomic analysis of cell envelope preparations under iron starvation stress in Aeromonas hydrophila.BMC microbiology · 2016Article
- Identification of learning-induced changes in protein networks in the hippocampi of a mouse model of Alzheimer's disease.Translational psychiatry · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVibrio parahaemolyticus is a common pathogen infecting humans and marine animals; this pathogen has become a major concern of marine food products and trade. In this study, V. parahaemolyticus isolated from sewage was exposed to different culture conditions and analyzed by isobaric tag for relative and absolute quantitation (iTRAQ) based reversed-phase liquid chromatography-tandem mass spectrometry (LC-MS/MS) technique. Our goal is to gain further insights into the proteomics of V. parahaemolyticus, particularly differentially expressed proteins closely correlated with growth conditions and pathogenicity associated proteins.
resultsIn this study, a total of 2,717 proteins including numerous membrane proteins were significantly identified, and 616 proteins displayed significant differential expression under different conditions. Of them, 12 proteins mainly participating in metabolism showed the most elastic expression differentiation between different culture conditions. Some membrane proteins such as type I secretion outer membrane protein, TolC, lipoprotein, efflux system proteins iron-regulated protein A and putaive Fe-regulated protein B, ferric siderophore receptor homolog and several V. parahaemolyticus virulence-associated proteins were differentially regulated under different conditions. Some differentially regulated proteins were analyzed and confirmed at gene expression level by quantitative real time polymerase chain reaction (qRT-PCR).
conclusionsProteomics analysis results revealed the characteristics of V. parahaemolyticus proteome expression, provided some promising biomarkers related with growth conditions, the results likely advance insights into the mechanism involved in the response of V. parahaemolyticus to different conditions. Some virulence-associated proteins were discovered to be differentially expressed under different conditions.
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