Evidence map›Paper›PMID 26224994›Full record

ArticleApplied magnetic resonance

ESR and X-ray Structure Investigations on the Binding and Mechanism of Inhibition of the Native State of Myeloperoxidase with Low Molecular Weight Fragments.

Balagopalakrishna Chavali, Thierry Masquelin, Mark J Nilges, David E Timm, Stephanie L Stout, William F Matter, Najia Jin, Prabhakar K Jadhav, Gary G Deng

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied magnetic resonance. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Balagopalakrishna ChavaliDivision of Tailored Therapeutics and Imaging, Lilly Corporate Center, Eli Lilly and Company, Bldg.87/C04, Column S17 DC 1940, 893 S Delaware Street, Indianapolis, IN 46285 USA.
Thierry MasquelinDiscovery Chemistry Research and Technologies, Lilly Corporate Center, Eli Lilly and Company, 893 S Delaware Street, Indianapolis, IN 46285 USA.
Mark J NilgesSchool of Molecular and Cellular Biology and Illinois EPR Research Center, Illinois EPR Research Center, 506 S. Mathews St., Urbana, IL 61801 USA.
David E TimmDiscovery Chemistry Research and Technologies, Lilly Corporate Center, Eli Lilly and Company, 893 S Delaware Street, Indianapolis, IN 46285 USA.
Stephanie L StoutDiscovery Chemistry Research and Technologies, Lilly Corporate Center, Eli Lilly and Company, 893 S Delaware Street, Indianapolis, IN 46285 USA.
William F MatterDivision of Endocrine and Cardiovascular Research, Lilly Corporate Center, Eli Lilly and Company, 893 S Delaware Street, Indianapolis, IN 46285 USA.
Najia JinDivision of Endocrine and Cardiovascular Research, Lilly Corporate Center, Eli Lilly and Company, 893 S Delaware Street, Indianapolis, IN 46285 USA.
Prabhakar K JadhavDiscovery Chemistry Research and Technologies, Lilly Corporate Center, Eli Lilly and Company, 893 S Delaware Street, Indianapolis, IN 46285 USA.
Gary G DengDivision of Endocrine and Cardiovascular Research, Lilly Corporate Center, Eli Lilly and Company, 893 S Delaware Street, Indianapolis, IN 46285 USA.
Eli Lilly (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As an early visitor to the injured loci, neutrophil-derived human Myeloperoxidase (hMPO) offers an attractive protein target to modulate the inflammation of the host tissue through suitable inhibitors. We describe a novel methodology of using low temperature ESR spectroscopy (6 K) and

Identifiers

PMID26224994
PMCPMC4515242
OpenAlexW1820446020

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.