ReviewThe Clinical biochemist. Reviews2015
Pleiotropic Activities of Vitamin D Receptors - Adequate Activation for Multiple Health Outcomes.
Review in The Clinical biochemist. Reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- High-dose oral vitamin D supplementation for prevention of infections in children aged 0 to 59 months: a systematic review and meta-analysis.Nutrition reviews · 2024Pooled it
- The effect of standard-dose wintertime vitamin D supplementation on influenza infection in immunized nursing home elderly residents.Croatian medical journal · 2021Trial
- Effect of an vitamin D deficiency on depressive symptoms in child and adolescent psychiatric patients - a randomized controlled trial: study protocol.BMC psychiatry · 2018Trial
- Vitamin D receptor signaling in inflammatory senescence-associated skin aging: Mechanisms and therapeutic potentials.Journal of cell communication and signaling · 2026Article
- Vitamin D-Mediated Immunoregulation in Degenerative Diseases: Insights into Cardiovascular, Neurodegenerative and Musculoskeletal Disorders.Nutrients · 2026Review
- Genetic insights into hepatocellular carcinoma: the role of VDR FokI (rs2228570) and TaqI (rs731236) polymorphisms in Egyptian patients.BMC medical genomics · 2026Article
- Relationship between serum vitamin D concentration and parameters of gonadal function in infertile male patients.Current urology · 2024Article
- Physiology of Vitamin D-Focusing on Disease Prevention.Nutrients · 2024Review
- The role of interaction between vitamin D and VDR FokI gene polymorphism (rs2228570) in sleep quality of adults.Scientific reports · 2024Article
- Tracing vitamins on the long non-coding lane of the transcriptome: vitamin regulation of LncRNAs.Genes & nutrition · 2024Review
- Cytomegalovirus results in poor graft function via bone marrow-derived endothelial progenitor cells.Frontiers in microbiology · 2024Article
- The immunomodulatory effects of vitamins in cancer.Frontiers in immunology · 2024Review
- Associations of serum 25-hydroxyvitamin D with serum folate, cobalanin, and homocysteine concentrations and methylene tetrahydrofolate reductase (MTHFR) gene polymorphisms in healthy adults.Hormones (Athens, Greece) · 2023Article
- Human Cytomegalovirus Induces Vitamin-D Resistance In Vitro by Dysregulating the Transcriptional Repressor Snail.Viruses · 2022Article
- Upregulation of VDR-associated lncRNAs in Schizophrenia.Journal of molecular neuroscience : MN · 2022Article
- Vitamin DFrontiers in pharmacology · 2022Article
- The Relationship Between Vitamin D, Clinical Manifestations, and Functional Network Connectivity in Female Patients With Major Depressive Disorder.Frontiers in aging neuroscience · 2022Article
- The relationship between nutrition and the immune system.Frontiers in nutrition · 2022Review
- The Most Common Vitamin D Receptor Polymorphisms (Children (Basel, Switzerland) · 2021Review
- The Calcitriol/Vitamin D Receptor System Regulates Key Immune Signaling Pathways in Chronic Lymphocytic Leukemia.Cancers · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The vitamin D receptor (VDR), a nuclear transcription factor, elicits physiological regulation of gene transcription following binding of its ligand, 1,25-dihydroxyvitamin D. The major biological activities of vitamin D contribute to regulation of plasma calcium and phosphate homeostasis and bone remodeling, although recent evidence suggests that vitamin D, like other steroid hormone receptors, can regulate a diverse range of biological activities across many tissues. Such properties raise the notion that vitamin D deficiency may not only be detrimental to bone and muscular health, but also a risk factor for a number of adverse health outcomes including increased risk of cardiovascular disease, inflammation, immune system disorders and cancer. Advances in transcriptional research provide data not only on ligand-dependent activities of the VDR, but other activities of vitamin D extending to rapid modulation of intra-cellular signaling pathways as well as apparent ligand-independent interactions between the VDR and other transcriptionally active proteins. In this review, we detail the chief molecular activities of the VDR in regulating gene transcription, intracellular signaling and actions of VDR via binding to transcriptional regulating proteins. The breadth of biological activities attributed to vitamin D informs clinical biochemists and health care professionals on the implications of vitamin D deficiency for health.
Identifiers
26224895PMC4504155W2408306070What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.