ArticleG3 (Bethesda, Md.)2015
The Genetics of Resistance to Morinda Fruit Toxin During the Postembryonic Stages in Drosophila sechellia.
Article in G3 (Bethesda, Md.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Intersecting experimental evolution and CRISPR screens to identify novel toxin resistance loci.eLife · 2026Article
- Genome-wide association studies identify new candidate genes and tissues underlying resistance to a natural toxin in drosophilids.G3 (Bethesda, Md.) · 2026Article
- Two major-effect loci influence interspecific mating in females of the sibling species, Drosophila simulans and D. sechellia.G3 (Bethesda, Md.) · 2025Article
- Genomic Islands of Divergence Between Drosophila yakuba Subspecies are Predominantly Driven by Chromosomal Inversions and the Recombination Landscape.Molecular ecology · 2025Article
- Genomics Analysis of L-DOPA Exposure inG3 (Bethesda, Md.) · 2019Article
- Investigating the role ofEcology and evolution · 2019Article
- Supervised machine learning reveals introgressed loci in the genomes of Drosophila simulans and D. sechellia.PLoS genetics · 2018Article
- Transcriptomic Analysis of Octanoic Acid Response inG3 (Bethesda, Md.) · 2017Article
- A nonrandom subset of olfactory genes is associated with host preference in the fruit flyEvolution letters · 2017Article
- Genetic basis of octanoic acid resistance in Drosophila sechellia: functional analysis of a fine-mapped region.Molecular ecology · 2017Article
- Drosophila yakuba mayottensis, a new model for the study of incipient ecological speciation.Fly · 2017Article
- Genetic dissection of intraspecific variation in a male-specific sexual trait in Drosophila melanogaster.Heredity · 2016Article
- Recurrent specialization on a toxic fruit in an island Drosophila population.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although a great deal has been learned regarding the genetic changes that give rise to adaptation in bacteria and yeast, an understanding of how new complex traits arise in multicellular organisms is far less complete. Many phytophagous insect species are ecological specialists that have adapted to utilize a single host plant. Drosophila sechellia is a specialist that utilizes the ripe fruit of Morinda citrifolia, which is toxic to its sibling species, D. simulans. Here we apply multiplexed shotgun genotyping and QTL analysis to examine the genetic basis of resistance to M. citrifolia fruit toxin in interspecific hybrids. We identify a locus of large effect on the third chromosome (QTL-IIIsima) in the D. simulans backcross that was not detected in previous analyses. We also identify a highly significant QTL of large effect on the X chromosome, QTL-Xsim. Additional smaller-effect loci were also identified in the D. simulans and D. sechellia backcrosses. We did not detect significant epistasis between loci. Instead, our analysis reveals large and smaller-effect loci that contribute to M. citrifolia resistance additively. The additive effect of each locus suggests that partial resistance to lower levels of M. citrifolia toxin could be passed through introgression from D. sechellia to D. simulans in nature. The identification of the major effect loci, QTL-IIIsima and QTL-Xsim, is an important step toward identifying the molecular basis of adaptation in a multicellular organism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.