Evidence map›Paper›PMID 26224616›Full record

ArticleInternational orthopaedics2016

Stromal vascular stem cell treatment decreases muscle fibrosis following chronic rotator cuff tear.

Jonathan P Gumucio, Michael D Flood, Stuart M Roche, Kristoffer B Sugg, Adeyiza O Momoh, Paul E Kosnik, Asheesh Bedi, Christopher L Mendias

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International orthopaedics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03332238 (A Phase II Study to Evaluate Autologous Stromal Vascular Fraction Cell Therapy to Improve the Repair of Chronically Rotator Cuff Tears), which is not on this map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03332238 phase2active not recruitingnot on this mapstarted 2019, after this paper: background citation

A Phase II Study to Evaluate Autologous Stromal Vascular Fraction Cell Therapy to Improve the Repair of Chronically Rotator Cuff Tears

TypeinterventionalSponsorHospital for Special Surgery, New YorkRan2019 to 2026Enrolled56ConditionsRotator Cuff Tear, Muscle Atrophy, Tendon TearArmsAutologous Stomal Vascular Fraction Material, Ringer's solution
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 39 citations in OpenAlex.

  1. Trial
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  12. Tendon and Ligament Healing and Current Approaches to Tendon and Ligament Regeneration.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020
    Review
  13. Article
  14. Cell therapy to improve regeneration of skeletal muscle injuries.Journal of cachexia, sarcopenia and muscle · 2019
    Review
  15. Use of stem cells and growth factors in rotator cuff tendon repair.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2019
    Review
  16. Biologics and stem cell-based therapies for rotator cuff repair.Annals of the New York Academy of Sciences · 2019
    Review
  17. Article
  18. Article
  19. Article
  20. Regenerative Engineering of the Rotator Cuff of the Shoulder.ACS biomaterials science & engineering · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jonathan P GumucioDepartment of Orthopaedic Surgery, University of Michigan Medical School, 109 Zina Pitcher Place, BSRB 2017, Ann Arbor, MI, 48109-2200, USA.
Michael D FloodDepartment of Orthopaedic Surgery, University of Michigan Medical School, 109 Zina Pitcher Place, BSRB 2017, Ann Arbor, MI, 48109-2200, USA.
Stuart M RocheDepartment of Orthopaedic Surgery, University of Michigan Medical School, 109 Zina Pitcher Place, BSRB 2017, Ann Arbor, MI, 48109-2200, USA.
Kristoffer B SuggDepartment of Orthopaedic Surgery, University of Michigan Medical School, 109 Zina Pitcher Place, BSRB 2017, Ann Arbor, MI, 48109-2200, USA.
Adeyiza O MomohDepartment of Surgery, Section of Plastic Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.
Paul E KosnikTissue Genesis, Inc., Honolulu, HI, USA.
Asheesh BediDepartment of Orthopaedic Surgery, University of Michigan Medical School, 109 Zina Pitcher Place, BSRB 2017, Ann Arbor, MI, 48109-2200, USA.
Christopher L MendiasDepartment of Orthopaedic Surgery, University of Michigan Medical School, 109 Zina Pitcher Place, BSRB 2017, Ann Arbor, MI, 48109-2200, USA. cmendias@umich.edu.
University of Michigan–Ann Arbor · USTissue Genesis (United States) · US

Funding

Sex Differences in Tendon Growth and RemodelingR01AR063649 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RODEO, SCOTT A · 2013 to 2022
$3.6M
The Role of Matrix Metalloproteinases in Tendon GrowthF32AR067086 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SUGG, KRISTOFFER BRADLEY · 2014 to 2016
$202k
Fatty Macrophage Regulation of Atrophy and Inflammation in Rotator Cuff TearsF31AR065931 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GUMUCIO, JONATHAN PAUL · 2014 to 2016
$103k
NIAMS NIH HHS F31 AR065931NIAMS NIH HHS F31-AR065931NIAMS NIH HHS F32 AR067086NIAMS NIH HHS F32-AR067086NIAMS NIH HHS R01 AR063649
6 · The paper itself

Abstract

purposeRotator cuff injuries are associated with atrophy and fat infiltration into the muscle, commonly referred to as "fatty degeneration." As the poor function of chronically torn muscles may limit recovery after surgical repair, there is considerable interest in finding therapies to enhance muscle regeneration. Stromal vascular fraction stem cells (SVFCs) can improve muscle regeneration in other chronic injury states, and our objective was to evaluate the ability of SVFCs to reduce fibrosis and fat accumulation, and enhance muscle fibre specific force production after chronic rotator cuff tear.

methodsChronic supraspinatus tears were induced in adult immunodeficient rats, and repaired one month following tear. Rats received vehicle control, or injections of 3 × 10(5) or 3 × 10(6) human SVFCs into supraspinatus muscles.

resultsTwo weeks following repair, we detected donor human DNA and protein in SVFC treated muscles. There was a 40 % reduction in fibrosis in the treated groups compared to controls (p = 0.03 for 3 × 10(5), p = 0.04 for 3 × 10(6)), and no differences between groups for lipid content or force production were observed.

conclusionsAs there has been much interest in the use of stem cell-based therapies in musculoskeletal regenerative medicine, the reduction in fibrosis and trend towards an improvement in single fiber contractility suggest that SVFCs may be beneficial to enhance the treatment and recovery of patients with chronic rotator cuff tears.

Indexed as

Rotator Cuff InjuriesWound HealingAdultAnimalsChronic DiseaseFibrosisHumansMaleMesenchymal Stem Cell TransplantationMuscle, SkeletalRatsRotator CuffStromal CellsTendon InjuriesFatty degenerationFibrosisMyosteatosisRotator cuffStromal vascular fraction stem cell

Identifiers

PMID26224616
PMCPMC4733427
OpenAlexW965894338

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.