ArticleJournal of the Royal Society, Interface2015
Cell shape regulation through mechanosensory feedback control.
Article in Journal of the Royal Society, Interface, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Models of Cellular Mechanosensation.Results and problems in cell differentiation · 2026Review
- A continuum model of mechanosensation based on contractility kit assembly.Biophysical journal · 2025Article
- Specific prostaglandins are produced in the migratory cells and the surrounding substrate to promotebioRxiv : the preprint server for biology · 2023Article
- Specific prostaglandins are produced in the migratory cells and the surrounding substrate to promoteFrontiers in cell and developmental biology · 2023Article
- Chemical characterization of non-psychoactive Cannabis sativa L. extracts, in vitro antiproliferative activity and induction of apoptosis in chronic myelogenous leukaemia cancer cells.Phytotherapy research : PTR · 2022Article
- Fascin limits Myosin activity withineLife · 2021Article
- An optogenetic model reveals cell shape regulation through FAK and fascin.Journal of cell science · 2021Article
- How the mechanobiome drives cell behavior, viewed through the lens of control theory.Journal of cell science · 2019Review
- The mechanobiology of actin cytoskeletal proteins during cell-cell fusion.Journal of the Royal Society, Interface · 2019Article
- Myosin IIB assembly state determines its mechanosensitive dynamics.The Journal of cell biology · 2019Article
- Mechanical phenotyping of K562 cells by the Micropipette Aspiration Technique allows identifying mechanical changes induced by drugs.Scientific reports · 2018Article
- Mechanochemical Signaling Directs Cell-Shape Change.Biophysical journal · 2017Review
- Dynamic myosin activation promotes collective morphology and migration by locally balancing oppositional forces from surrounding tissue.Molecular biology of the cell · 2016Article
- Mechanoaccumulative Elements of the Mammalian Actin Cytoskeleton.Current biology : CB · 2016Article
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Authors and funding
4 authors.
Funding
Abstract
Cells undergo controlled changes in morphology in response to intracellular and extracellular signals. These changes require a means for sensing and interpreting the signalling cues, for generating the forces that act on the cell's physical material, and a control system to regulate this process. Experiments on Dictyostelium amoebae have shown that force-generating proteins can localize in response to external mechanical perturbations. This mechanosensing, and the ensuing mechanical feedback, plays an important role in minimizing the effect of mechanical disturbances in the course of changes in cell shape, especially during cell division, and likely in other contexts, such as during three-dimensional migration. Owing to the complexity of the feedback system, which couples mechanical and biochemical signals involved in shape regulation, theoretical approaches can guide further investigation by providing insights that are difficult to decipher experimentally. Here, we present a computational model that explains the different mechanosensory and mechanoresponsive behaviours observed in Dictyostelium cells. The model features a multiscale description of myosin II bipolar thick filament assembly that includes cooperative and force-dependent myosin-actin binding, and identifies the feedback mechanisms hidden in the observed mechanoresponsive behaviours of Dictyostelium cells during micropipette aspiration experiments. These feedbacks provide a mechanistic explanation of cellular retraction and hence cell shape regulation.
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Registered trials
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