Evidence map›Paper›PMID 26224446›Full record

ArticleCancer science2015

Long non-coding RNA Fer-1-like protein 4 suppresses oncogenesis and exhibits prognostic value by associating with miR-106a-5p in colon cancer.

Ben Yue, Bo Sun, Chenchen Liu, Senlin Zhao, Dongyuan Zhang, Fudong Yu, Dongwang Yan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 4 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 4 syntheses or guidelines pooled it, 112 citations in OpenAlex.

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18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ben YueDepartment of General Surgery, Shanghai Jiao Tong University Affiliated First People's Hospital, Shanghai, China.
Bo SunDepartment of Pharmacy, Shanghai Jiao Tong University Affiliated First People's Hospital, Shanghai, China.
Chenchen LiuDepartment of General Surgery, Shanghai Jiao Tong University Affiliated First People's Hospital, Shanghai, China.
Senlin ZhaoDepartment of General Surgery, Shanghai Jiao Tong University Affiliated First People's Hospital, Shanghai, China.
Dongyuan ZhangDepartment of General Surgery, Shanghai Jiao Tong University Affiliated First People's Hospital, Shanghai, China.
Fudong YuDepartment of General Surgery, Shanghai Jiao Tong University Affiliated First People's Hospital, Shanghai, China.
Dongwang YanDepartment of General Surgery, Shanghai Jiao Tong University Affiliated First People's Hospital, Shanghai, China.
Shanghai Jiao Tong University · CNShanghai First People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Novel long non-coding RNA Fer-1-like protein 4 (FER1L4) has been confirmed to play crucial regulatory roles in tumor progression. It exerts an impact on tumor suppression and functions as a competing endogenous RNA (ceRNA) by sponging miR-106a-5p in gastric cancer. However, its clinical significance in colon cancer is completely unknown. The aim of the present study was to annotate the role of FER1L4 and its clinical value in colon cancer. The results showed the aberrant expression of FER1L4 and miR-106a-5p in colon cancer tissues. In addition, significant negative correlation between FER1L4 and miR-106a-5p expression levels was observed. Among the colon cancer cell lines, FER1L4 levels were relatively lower, with concurrent high levels of miR-106a-5p. Restoration of FER1L4 decreased the expression of miR-106a-5p, and had a significant influence on colon cancer cell proliferation, migration and invasion. The FER1L4 expression was correlated with depth of tumor invasion, lymph node metastasis, vascular invasion and clinical stage. Moreover, striking differences in overall survival and disease-free survival were observed for the cases with both low FER1L4 expression and high miR-106a-5p expression compared with cases with high FER1L4 expression and low miR-106a-5p expression. Circulating FER1L4 and miR-106a-5p levels were decreased and increased, respectively, in colon cancer patients after surgery. Our findings indicated that FER1L4 could exert a tumor suppressive impact on colon cancer, which at least, in part, through suppressing miR-106a-5p expression, and depletion of FER1L4, alone or combined with overexpression of miR-106a-5p, is predictive of poor prognosis in colon cancer and may play a crucial role in cancer prevention and treatment.

Indexed as

AdultAgedAged, 80 and overCell Line, TumorCell MovementCell ProliferationCell Transformation, NeoplasticColonic NeoplasmsFemaleGene Expression Regulation, NeoplasticHCT116 CellsHumansLymphatic MetastasisMaleMicroRNAsMiddle Agedlong non-coding RNA FER1L4, humanMicroRNAsMIRN106 microRNA, humanRNA, Long Noncodingcolon cancerFER1L4MiR-106a-5pprognosistumor marker

Identifiers

PMID26224446
PMCPMC4638023
OpenAlexW1908070363

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.