ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2015
Efficacy of Common Analgesics for Postsurgical Pain in Rats.
Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Grimace scale, burrowing, and nest building for the assessment of post-surgical pain in mice and rats-A systematic review.Frontiers in veterinary science · 2022Pooled it
- Onset of Analgesia in Rats (Rattus norvegicus) for Three Buprenorphine Formulations.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- Synergistic effects of repeated transcranial magnetic stimulation and mesenchymal stem cells transplantation on alleviating neuroinflammation and PANoptosis in cerebral ischemia.Journal of neuroinflammation · 2024Article
- A Retrospective Report of Carprofen Administration as Post-Operative Analgesia Reveals Negative Effects of Recommended Doses.Animals : an open access journal from MDPI · 2024Article
- The grimace scale: a useful tool for assessing pain in laboratory animals.Experimental animals · 2024Review
- Refinement of the motorised laminectomy-assisted rat spinal cord injury model by analgesic treatment.PloS one · 2024Article
- Review of Rat (Animals : an open access journal from MDPI · 2023Review
- Comparison of Nociceptive Effects of Buprenorphine, Firocoxib, and Meloxicam in a Plantar Incision Model in Sprague-Dawley Rats.Journal of the American Association for Laboratory Animal Science : JAALAS · 2021Article
- Hypothermia During General Anesthesia Interferes with Pain Assessment in Laboratory Rats (Journal of the American Association for Laboratory Animal Science : JAALAS · 2020Article
- The Utility of Grimace Scales for Practical Pain Assessment in Laboratory Animals.Animals : an open access journal from MDPI · 2020Review
- Grimace Scores: Tools to Support the Identification of Pain in Mammals Used in Research.Animals : an open access journal from MDPI · 2020Review
- Intraperitoneal injection of sodium pentobarbital has the potential to elicit pain in adult rats (Rattus norvegicus).PloS one · 2020Article
- Association of Intranasal and Neurogenic Dural Inflammation in Experimental Acute Rhinosinusitis.Frontiers in pharmacology · 2020Article
- Concentration-dependent Toxicity after Subcutaneous Administration of Meloxicam to C57BL/6N Mice (Journal of the American Association for Laboratory Animal Science : JAALAS · 2019Article
- Analgesia during Monkeypox Virus Experimental Challenge Studies in Prairie Dogs (Journal of the American Association for Laboratory Animal Science : JAALAS · 2019Article
- Baseline performance of the ischaemic button model for induction of adhesions in laboratory rats.Laboratory animals · 2019Article
- Evaluating analgesic efficacy and administration route following craniotomy in mice using the grimace scale.Scientific reports · 2019Article
- Blocking of BDNF-TrkB signaling inhibits the promotion effect of neurological function recovery after treadmill training in rats with spinal cord injury.Spinal cord · 2019Article
- Article
- Augmenting the antinociceptive effects of nicotinic acetylcholine receptor activity through lynx1 modulation.PloS one · 2018Article
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Each year, millions of rats undergo surgery for research purposes and receive analgesics to alleviate pain. We sought to evaluate the efficacy of common analgesics in tests of hot-plate nociception and postsurgical pain by using the Rat Grimace Scale. Rats received a single dose of one of several drug-dose combinations and were tested by using the hot-plate test (acute pain) or after laparotomy (with either prophylactic or intraoperative analgesic). The efficacy of analgesics for hot-plate pain was generally not predictive of efficacy for surgical pain. Carprofen and ketoprofen were rarely effective in any of the conditions tested. With the exception of the opioid buprenorphine, several of the drugs we tested required higher-than-recommended doses to alleviate pain. Taken together, our data suggest that current analgesic use frequently is insufficient, and many rats may experience significant postsurgical pain even when analgesics are used in commonly recommended doses.
Indexed as
Identifiers
26224443PMC4521577W2415175826What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.