Evidence map›Paper›PMID 26224401›Full record

ArticleAmerican journal of hypertension2016

Associations Between Genetic Variants of the Natriuretic Peptide System and Blood Pressure Response to Dietary Sodium Intervention: The GenSalt Study.

Shufeng Chen, Jianfeng Huang, Qi Zhao, Jing Chen, Cashell E Jaquish, Jiang He, Xiangfeng Lu, Xueli Yang, Charles C Gu, James E Hixson and 5 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of hypertension, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Shufeng ChenState Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; shufengchen2001@163.com.
Jianfeng HuangState Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;
Qi ZhaoDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, USA;
Jing ChenDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, USA;
Cashell E JaquishNational Heart, Lung, and Blood Institute, National Institute of Health, Bethesda, Maryland, USA;
Jiang HeDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, USA;
Xiangfeng LuState Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;
Xueli YangState Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;
Charles C GuSchool of Medicine, Washington University, St. Louis, Missouri, USA;
James E HixsonSchool of Public Health, University of Texas, Houston, Texas, USA.
Fangchao LiuState Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;
Treva K RiceSchool of Medicine, Washington University, St. Louis, Missouri, USA;
Jie CaoState Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;
Jichun ChenState Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;
Dongfeng GuState Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;
Chinese Academy of Medical Sciences & Peking Union Medical College · CNTulane University · USWashington University in St. Louis · USNational Heart Lung and Blood Institute · US

Funding

Genetic Epidemiology of Blood Pressure InterventionU01HL072507 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI HE, JIANG · 2002 to 2008
$7.6M
Family-Based Genome-wide Association Study for Salt-Sensitivity of Blood PressureR01HL090682 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI HE, JIANG · 2008 to 2011
$2.8M
Sodium Sensitivity and Risk of HypertensionR01HL087263 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI HE, JIANG · 2007 to 2011
$2.8M
Research Training in Gene-Environment Interaction in ChinaD43TW009107 · FIC · TULANE UNIVERSITY OF LOUISIANA · PI GU, DONGFENG, HE, JIANG · 2012 to 2016
$1.1M
FIC NIH HHS D43 TW009107NHLBI NIH HHS R01 HL087263NHLBI NIH HHS R01HL087263NHLBI NIH HHS R01 HL090682NHLBI NIH HHS R01HL090682NHLBI NIH HHS U01 HL072507NHLBI NIH HHS U01HL072507
6 · The paper itself

Abstract

backgroundThe aim of this study was to comprehensively test the association of genetic variants in the natriuretic peptide (NP) system with blood pressure (BP) response to dietary sodium intervention in a Chinese population.

methodsWe conducted a 7-day low-sodium intervention followed by a 7-day high-sodium intervention among 1,906 participants in rural China. BP measurements were obtained at baseline and each dietary intervention using a random-zero sphygmomanometer. Linear mixed-effect models were used to assess the associations of 48 single-nucleotide polymorphisms (SNPs) in 6 genes of NP system with BP response to dietary sodium intervention.

resultsSNP rs5063 in the NPPA gene and SNP rs2077386 in the NPPC gene exhibited significant associations with BP response to low-sodium dietary intervention under recessive genetic model. For rs5063, absolute mean arterial pressure responses (95% confidence interval) to the low-sodium intervention were 1.31 (-1.08, 3.70) mm Hg for TT genotype and -3.74 (-4.01, -3.46) mm Hg for CC or TC genotype, respectively (P = 4.1 × 10(-5)). Individuals with at least one copy of the C allele of rs2077386 had significantly reduction in systolic BP during the low-sodium intervention compared to those with genotype GG with responses of -5.48 (-5.83, -5.14) vs. -2.76 (-3.52, -2.00) mm Hg, respectively (P = 1.9 × 10(-13)).

conclusionsThese novel findings suggested that genetic variants of NP system may contribute to the variation of BP response to sodium intervention in Chinese population. Certainly, replication of these results in other populations and further functional studies are warranted to clarify their role in the regulation of BP and hypertension.

Indexed as

Diet, Sodium-RestrictedAdultAllelesAsian PeopleAtrial Natriuretic FactorAtrial Natriuretic Factor Receptor BBlood PressureFemaleGenetic VariationGenotypeHumansMaleMiddle AgedNatriuretic Peptide, BrainNatriuretic Peptide, C-TypeNatriuretic PeptidesAtrial Natriuretic Factoratrial natriuretic factor receptor AAtrial Natriuretic Factor Receptor Batrial natriuretic factor receptor CNatriuretic Peptide, BrainNatriuretic Peptide, C-TypeNatriuretic PeptidesNPPA protein, humanReceptors, Atrial Natriuretic FactorSodium, Dietaryblood pressure responsedietary interventiongenetic associationnatriuretic peptide.

Identifiers

PMID26224401
PMCPMC4757957
OpenAlexW2337792216

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.