ArticleBMC neurology2015
Effect of pre-stroke statin use on stroke severity and early functional recovery: a retrospective cohort study.
Article in BMC neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Annual Trends in Risk Factor Control Status at the Time of Ischemic Stroke in South Korea.Journal of the American Heart Association · 2026Article
- Article
- CT Perfusion Imaging in Patients with Acute Ischemic Stroke: The Role of Premorbid Statin Treatment.Tomography (Ann Arbor, Mich.) · 2025Article
- Temporal Trends in Stroke Management and Outcomes Between 2011 and 2020 in South Korea: Results From a Nationwide Multicenter Registry.Journal of the American Heart Association · 2025Article
- Lipid-Lowering Therapy Use When Indicated and Subsequent Ischemic Stroke Severity.Journal of the American Heart Association · 2025Article
- Prognosis of ischemic stroke patients with both aortic atheroma and cardioembolic sources.Scientific reports · 2024Article
- Medical Management of Dyslipidemia for Secondary Stroke Prevention: Narrative Review.Medicina (Kaunas, Lithuania) · 2023Review
- Pre-Stroke Statin Use Is Associated with Mild Neurological Deficits at the Onset of Acute Ischemic Stroke.Journal of cardiovascular development and disease · 2022Article
- Neuroinflammation in Cerebral Ischemia and Ischemia/Reperfusion Injuries: From Pathophysiology to Therapeutic Strategies.International journal of molecular sciences · 2021Review
- Cholesterol reducer and thrombolytic therapy in acute ischemic stroke patients.Lipids in health and disease · 2020Article
- Association of prestroke medicine use and health outcomes after ischaemic stroke in Sweden: a registry-based cohort study.BMJ open · 2020Article
- Low-dose statin pretreatment reduces stroke severity and improves functional outcomes.Journal of neurology · 2019Article
- Current and Emerging Uses of Statins in Clinical Therapeutics: A Review.Lipid insights · 2016Review
- Statins in Acute Ischemic Stroke: A Systematic Review.Journal of stroke · 2015Review
Corrections and comments
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Authors and funding
22 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExperimental studies suggest that pre-stroke statin treatment has a dual effect of neuroprotection during ischemia and neurorestoration after ischemic injury. The aim of this study was to evaluate the effect of pre-stroke statin use on initial stroke severity and early clinical outcome.
methodsWe used a prospective database enrolling patients with acute ischemic stroke from 12 hospitals in Korea between April 2008 and January 2012. Primary endpoint was the initial stroke severity as measured by the National Institutes of Health Stroke Scale (NIHSS) score. Secondary endpoints were good outcome (modified Rankin Scale [mRS], 0-2) and overall mRS distribution at discharge. Multivariable regression model and propensity score (PS) matching were used for statistical analyses.
resultsAmong the 8340 patients included in this study, 964 patients (11.6%) were pre-stroke statin users. The initial NIHSS score (mean [95% CI]) was lower among pre-stroke statin users vs. non-users in multivariable analysis (5.7 [5.2-6.3] versus 6.4 [5.9-6.9], p = 0.002) and PS analysis (5.2 [4.7-5.7] versus 5.7 [5.4-6.0], p = 0.043). Pre-stroke statin use was associated with increased achievement of mRS 0-2 outcome (multivariable analysis: OR [95% CI], 1.55 [1.25-1.92], p < 0.001; PS matching: OR [95% CI], 1.47 [1.16-1.88]; p = 0.002) and favorable shift on the overall mRS distribution (multivariable analysis: OR [95% CI], 1.29 [1.12-1.51], p = 0.001; PS matching: OR [95% CI], 1.31 [1.11-1.54]; p = 0.001).
conclusionsPre-stroke statin use was independently associated with lesser stroke severity at presentation and better early functional recovery in patients with acute ischemic stroke.
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