Evidence map›Paper›PMID 26224101›Full record

ArticleDiabetologia2015

Mechanisms through which a small protein and lipid preload improves glucose tolerance.

Domenico Tricò, Simona Baldi, Alberto Tulipani, Silvia Frascerra, Maria Paula Macedo, Andrea Mari, Ele Ferrannini, Andrea Natali

Registry-linked trialOpen access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Diabetologia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02342834 (Mechanisms Through Which a Small Protein and Lipid Preload Improves Glucose Tolerance in Subjects With Impaired Glucose Homeostasis), which is not on this map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02342834 nacompletednot on this map

Mechanisms Through Which a Small Protein and Lipid Preload Improves Glucose Tolerance in Subjects With Impaired Glucose Homeostasis

TypeinterventionalSponsorAzienda Ospedaliero, Universitaria PisanaRan2015 to 2020Enrolled35ConditionsDiabetes Mellitus, Type 2ArmsSmall mixed protein and lipid meal
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.

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  17. Manipulation of Post-Prandial Hyperglycaemia in Type 2 Diabetes: An Update for Practitioners.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024
    Review
  18. Article
  19. Review
  20. [Nutrition for diabetic patients (Update 2023)].Wiener klinische Wochenschrift · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Domenico TricòDepartment of Clinical and Experimental Medicine, University of Pisa, Via Roma 57, Pisa, 56100, Italy. domenico.trico@for.unipi.it.
Simona BaldiDepartment of Clinical and Experimental Medicine, University of Pisa, Via Roma 57, Pisa, 56100, Italy.
Alberto TulipaniDepartment of Clinical and Experimental Medicine, University of Pisa, Via Roma 57, Pisa, 56100, Italy.
Silvia FrascerraDepartment of Clinical and Experimental Medicine, University of Pisa, Via Roma 57, Pisa, 56100, Italy.
Maria Paula MacedoCEDOC, NOVA Medical School/Faculdade de Ciencias Medicas (NMS/FCM), Universidade Nova de Lisboa, Lisboa, Portugal.
Andrea MariNational Research Council, Institute of Neuroscience, Padua, Italy.
Ele FerranniniDepartment of Clinical and Experimental Medicine, University of Pisa, Via Roma 57, Pisa, 56100, Italy.
Andrea NataliDepartment of Clinical and Experimental Medicine, University of Pisa, Via Roma 57, Pisa, 56100, Italy.
University of Pisa · ITNational Research Council · ITUniversidade Nova de Lisboa · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aims/hypothesisSmall protein or lipid preloads are able to improve glucose tolerance to a different extent and through different and poorly defined mechanisms. We aimed at quantifying the effect of a mixed protein and lipid preload and at evaluating the underlying mechanisms.

methodsVolunteers with normal (NGT, n = 12) or impaired (IGT, n = 13) glucose tolerance and patients with type 2 diabetes (n = 10) underwent two OGTTs coupled to the double glucose tracer protocol, preceded by either 50 g of parmesan cheese, a boiled egg and 300 ml of water, or 500 ml of water. We measured plasma glucose, insulin, C-peptide, glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), pancreatic polypeptide (PP), NEFA and glucose tracers, and calculated glucose fluxes, beta cell function variables, insulin sensitivity and clearance.

resultsAfter the nutrient preload, the OGTT-induced rise of plasma glucose was lower than after water alone in each study group. This reduction—more pronounced across classes of glucose tolerance (NGT -32%, IGT -37%, type 2 diabetes -49%; p < 0.002)—was the result of different combinations of slower exogenous glucose rate of appearance, improved beta cell function and reduced insulin clearance, in this order of relevance, which were associated with an only mild stimulation of GIP and GLP-1. CONCLUSIONS/

interpretationAfter a non-glucidic nutrient preload, glucose tolerance improved in proportion to the degree of its baseline deterioration through mechanisms that appear particularly effective in type 2 diabetes. Exploiting the physiological responses to nutrient ingestion might reveal, at least in the first stages of the diabetic disease, a potent tool to improve daily life glycaemic control.

trial registrationClinicalTrials.gov NCT02342834

fundingThis work was supported by grants from the University of Pisa (Fondi di Ateneo) and by FCT grant (PIC/IC/82956/2007).

Indexed as

Blood GlucoseAdolescentAdultAgedC-PeptideDiabetes Mellitus, Type 2Dietary FatsDietary ProteinsFemaleGlucagon-Like Peptide 1Glucose IntoleranceGlucose Tolerance TestHumansInsulinMaleMiddle AgedBlood GlucoseC-PeptideDietary FatsDietary ProteinsGlucagon-Like Peptide 1InsulinBeta cell functionGlucose absorptionGlucose intoleranceHepatic glucose productionInsulin secretion in vivoInsulin sensitivityLipidProteinType 2 diabetes

Identifiers

PMID26224101
OpenAlexW1006766939

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.