ArticleScientific reports2015
Disinhibition-induced transitions between absence and tonic-clonic epileptic seizures.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 52 citations in OpenAlex.
- The role of extracellular glutamate homeostasis dysregulated by astrocyte in epileptic discharges: a model evidence.Cognitive neurodynamics · 2024Article
- Dynamic effect of electromagnetic induction on epileptic waveform.BMC neuroscience · 2022Article
- The Critical Modulatory Role of Spiny Stellate Cells in Seizure Onset Based on Dynamic Analysis of a Neural Mass Model.Frontiers in neuroscience · 2021Article
- Dynamic Transitions in Neuronal Network Firing Sustained by Abnormal Astrocyte Feedback.Neural plasticity · 2020Article
- Article
- Controlling mechanism of absence seizures by deep brain stimulus applied on subthalamic nucleus.Cognitive neurodynamics · 2018Article
- Characterisation of ictal and interictal states of epilepsy: A system dynamic approach of principal dynamic modes analysis.PloS one · 2018Article
- Stimulus-induced transitions between spike-wave discharges and spindles with the modulation of thalamic reticular nucleus.Journal of computational neuroscience · 2017Article
- Combined Effects of Feedforward Inhibition and Excitation in Thalamocortical Circuit on the Transitions of Epileptic Seizures.Frontiers in computational neuroscience · 2017Article
- Prediction of the Seizure Suppression Effect by Electrical Stimulation via a Computational Modeling Approach.Frontiers in computational neuroscience · 2017Article
- Control of Absence Seizures by the Thalamic Feed-Forward Inhibition.Frontiers in computational neuroscience · 2017Article
- Stimulus-induced Epileptic Spike-Wave Discharges in Thalamocortical Model with Disinhibition.Scientific reports · 2016Article
- The synchronization of neuronal oscillators determined by the directed network structure of the suprachiasmatic nucleus under different photoperiods.Scientific reports · 2016Article
- Stimulus-dependent synchronization in delayed-coupled neuronal networks.Scientific reports · 2016Article
- Heterogeneity induces rhythms of weakly coupled circadian neurons.Scientific reports · 2016Article
- Disinhibition-Induced Delayed Onset of Epileptic Spike-Wave Discharges in a Five Variable Model of Cortex and Thalamus.Frontiers in computational neuroscience · 2016Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Electrophysiological experiments have long revealed the existence of two-way transitions between absence and tonic-clonic epileptic seizures in the cerebral cortex. Based on a modified spatially-extended Taylor &Baier neural field model, we here propose a computational framework to mathematically describe the transition dynamics between these epileptic seizures. We first demonstrate the existence of various transition types that are induced by disinhibitory functions between two inhibitory variables in an isolated Taylor &Baier model. Moreover, we show that these disinhibition-induced transitions can lead to stable tonic-clonic oscillations as well as periodic spike with slow-wave discharges, which are the hallmark of absence seizures. We also observe fascinating dynamical states, such as periodic 2-spike with slow-wave discharges, tonic death, bursting oscillations, as well as saturated firing. Most importantly, we identify paths that represent physiologically plausible transitions between absence and tonic-clonic seizures in the modified spatially-extended Taylor &Baier model.
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