ArticleJournal of neural transmission (Vienna, Austria : 1996)2015
No association of FAM47E rs6812193, SCARB2 rs6825004 and STX1B rs4889603 polymorphisms with Parkinson's disease in a Chinese Han population.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- Fibroblasts from idiopathic Parkinson's disease exhibit deficiency of lysosomal glucocerebrosidase activity associated with reduced levels of the trafficking receptor LIMP2.Molecular brain · 2021Article
- Lysosomal Storage Disorders Shed Light on Lysosomal Dysfunction in Parkinson's Disease.International journal of molecular sciences · 2020Review
- Polymorphisms ofParkinson's disease · 2019Article
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Authors and funding
11 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Recently, a series of studies found that the single-nucleotide polymorphisms (SNPs) rs6812193 in the family with sequence similarity 47, member E (FAM47E), rs6825004 in the scavenger receptor class B member 2 (SCARB2) and rs4889603 in the Syntaxin1B (STX1B) genes increase the risk for Parkinson's disease (PD). However, the results of subsequent independent studies were inconsistent. To explore the associations between the three SNPs and PD in the Chinese population, a large cohort was analyzed in a case-control study. A total of 1994 subjects, including 1179 PD and 815 healthy controls (HCs), were investigated. All subjects were genotyped for rs6812193, rs6825004 and rs4889603 using the Sequenom iPLEX Assay. There was no significant difference in additive genetic model of rs6812193, rs6825004 and rs4889603 between PD and controls, even after being stratified by sex and age. In addition, no significant differences were found between other subgroups of PD patients with regard to clinical presentation. Our findings suggested that FAM47E rs6812193, SCARB2 rs6825004 and STX1B rs4889603 do not confer a significant risk for PD in Chinese population.
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