Evidence map›Paper›PMID 26224016›Full record

Trial reportBMJ open2015

Proposal for an annual skin examination by a general practitioner for patients at high risk for melanoma: a French cohort study.

Cédric Rat, Charlotte Grimault, Gaelle Quereux, Maelenn Dagorne, Aurélie Gaultier, Amir Khammari, Brigitte Dreno, Jean-Michel Nguyen

Registry-linked trialOpen access · goldAbstract readClinical Trial
In one paragraph

Trial report in BMJ open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01610531 (COPARIME), which is not on this map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01610531 nacompletednot on this map

COPARIME: Pilot Study of a Target Detection of Malignant Melanoma

TypeinterventionalSponsorNantes University HospitalRan2011 to 2018Enrolled4,118ConditionsPatients at Risk for MelanomaArmsSAMScore questionnaire
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Melanoma Prevention: Comparison of Different Screening Methods for the Selection of a High Risk Population.International journal of environmental research and public health · 2021
    Article
  5. Article
  6. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Cédric RatDepartment of General Practice, Faculty of Medicine, Nantes, France French National Institute of Health and Medical Research (INSERM U892)/National Centre for Scientific Research (CNRS U6299)-Team 2, Nantes, France.
Charlotte GrimaultDepartment of General Practice, Faculty of Medicine, Nantes, France.
Gaelle QuereuxFrench National Institute of Health and Medical Research (INSERM U892)/National Centre for Scientific Research (CNRS U6299)-Team 2, Nantes, France Oncodermatology Department, Nantes University Hospital, Nantes, France.
Maelenn DagorneDepartment of General Practice, Faculty of Medicine, Nantes, France.
Aurélie GaultierDepartment of Epidemiology and Biostatistics, Nantes University Hospital, Nantes, France.
Amir KhammariFrench National Institute of Health and Medical Research (INSERM U892)/National Centre for Scientific Research (CNRS U6299)-Team 2, Nantes, France Oncodermatology Department, Nantes University Hospital, Nantes, France.
Brigitte DrenoFrench National Institute of Health and Medical Research (INSERM U892)/National Centre for Scientific Research (CNRS U6299)-Team 2, Nantes, France Oncodermatology Department, Nantes University Hospital, Nantes, France.
Jean-Michel NguyenFrench National Institute of Health and Medical Research (INSERM U892)/National Centre for Scientific Research (CNRS U6299)-Team 2, Nantes, France Department of Epidemiology and Biostatistics, Nantes University Hospital, Nantes, France.
Inserm · FRCentre National de la Recherche Scientifique · FRNantes Université · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the efficacy of a targeted screening for melanoma in high-risk patients following the receipt of a mailed invitation to an annual skin examination by a general practitioner (GP).

methodsA prospective cohort study was conducted in a primary care setting in western France. A total of 3897 patients at elevated risk of melanoma (identified using the Self-Assessment of Melanoma Risk Score) consented to participate in a targeted melanoma screening project in 2011. One year later, the participants were invited by mail to consult their GP for an annual skin examination. Efficacy of the procedure was evaluated according to patient participation and the number of melanomas detected. The consultation dates and results were collected during the 12 months postreminder and were analysed using SAS. Analyses of whether participation decreased compared with that during the year of inclusion and whether populations at risk for thick melanoma showed reduced participation in the screening were performed.

resultsOf the 3745 patients who received the mailed invitation, 61% underwent a skin examination. The participation of patients at risk for thick melanoma (any patient over 60 years of age and men over 50 years of age) was significantly greater than that of the patients in the other subgroups (72.4% vs 49.6%, p<0.001; and 66% vs 52.4%, p<0.001, respectively). The patients referred to the dermatologist after 1 year were more compliant compared with those referred during the first year (68.8% vs 59.1%, p=0.003). Six melanomas were detected within 1 year postreminder; therefore, the incidence of melanoma in the study population was 160/100 000.

conclusionsThis study confirms the benefits of developing a targeted screening strategy in primary care. In particular, after the annual reminder, patient participation and the diagnosis of melanoma remained high in the patients at elevated risk of thick melanomas. TRIAL REGISTRATION NUMBER: NCT01610531.

Indexed as

AdultAgedCohort StudiesEarly Detection of CancerFemaleFranceGeneral PracticeGeneral PractitionersHumansMaleMelanomaMiddle AgedPatient CompliancePatient ParticipationPhysical ExaminationPilot ProjectsPREVENTIVE MEDICINEPRIMARY CAREPUBLIC HEALTH

Identifiers

PMID26224016
PMCPMC4521510
OpenAlexW1863465928

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.