Evidence map›Paper›PMID 26223981›Full record

ArticleBMC research notes2015

The CCR5Δ32 (rs333) polymorphism is not a predisposing factor for severe pandemic influenza in the Brazilian admixed population.

Alvino Maestri, Mirleide Cordeiro dos Santos, Elzemar M Ribeiro-Rodrigues, Wyller Alencar de Mello, Rita Catarina Medeiros Sousa, Sidney Emanuel dos Santos, Vinicius Albuquerque Sortica

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC research notes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Review
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  7. Review
  8. Influenza Pathogenesis: The Effect of Host Factors on Severity of Disease.Journal of immunology (Baltimore, Md. : 1950) · 2019
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Alvino MaestriLaboratório de Genética Humana e Médica, Universidade Federal do Pará, Cidade Universitária Prof. José da Silveira Neto, Rua Augusto Corrêa, 01, BOX: 8615, Belém, Pará, CEP: 66.075-970, Brazil. alvimaestri@hotmail.com.
Mirleide Cordeiro dos SantosLaboratory of Respiratory Viruses, Virology Section, Evandro Chagas Institute, Ananindeua, Pará, Brazil. mirleidesantos@iec.pa.gov.br.
Elzemar M Ribeiro-RodriguesLaboratório de Genética Humana e Médica, Universidade Federal do Pará, Cidade Universitária Prof. José da Silveira Neto, Rua Augusto Corrêa, 01, BOX: 8615, Belém, Pará, CEP: 66.075-970, Brazil. elze_mar@yahoo.com.br.
Wyller Alencar de MelloTropical Medicine Institute, Federal University of Pará, Belém, Pará, Brazil. wyllermello@iec.pa.gov.br.
Rita Catarina Medeiros SousaTropical Medicine Institute, Federal University of Pará, Belém, Pará, Brazil. ritasousa@iec.pa.gov.br.
Sidney Emanuel dos SantosLaboratório de Genética Humana e Médica, Universidade Federal do Pará, Cidade Universitária Prof. José da Silveira Neto, Rua Augusto Corrêa, 01, BOX: 8615, Belém, Pará, CEP: 66.075-970, Brazil. sidneysantos@ufpa.br.
Vinicius Albuquerque SorticaCenter of Cancer Research, Federal University of Pará, Belém, Pará, Brazil. vsortica@hotmail.com.
Universidade Federal do Pará · BRInstituto Evandro Chagas · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecent studies have tried to identify host genetic variants that could explain severe cases and deaths in infection with Influenza A(H1N1)pdm09, especially among children and young adults. CCR5 is a chemokine receptor expressed on T cells, macrophages and dendritic cells, which is an important mediator of leukocyte chemotaxis during the immune response. A deletion mutation (Δ32) in this gene interferes with the response of immune cells, impairing viral clearance. We evaluated the CCR5Δ32 polymorphism (rs333) in individuals of the Brazilian admixed population with a diagnosis of Influenza A(H1N1)pdm09 infection.

methodsA total of 330 subjects with a diagnosis of Influenza A(H1N1)pdm09, evaluated at health services in the northern and northeastern regions of Brazil between June 2009 and August 2010, were genotyped for the Δ32 deletion (rs333). The cases were classified according to the progression of infection into a group of hospitalized patients (n = 156) and a group of non-hospitalized patients (n = 174).

resultsNo significant differences in the allele or genotype frequencies of the CCR5Δ32 polymorphism were observed between non-hospitalized and hospitalized patients (p = 0.289 and p = 0.431, respectively).

conclusionThe Δ32 deletion in the CCR5 gene is not associated with an unfavorable outcome in patients infected with Influenza A(H1N1)pdm09 in the Brazilian admixed population.

Indexed as

AdolescentAdultAgedAged, 80 and overBase SequenceBrazilChildChild, PreschoolFemaleGene ExpressionHospitalizationHumansInfantInfluenza A Virus, H1N1 SubtypeInfluenza, HumanLeukocytes, MononuclearCCR5 protein, humanReceptors, CCR5

Identifiers

PMID26223981
PMCPMC4520097
OpenAlexW1535078245

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.