Evidence map›Paper›PMID 26223890›Full record

ArticleCancer causes & control : CCC2015

Persistence of Trichomonas vaginalis serostatus in men over time.

Siobhan Sutcliffe, John F Alderete, Calvin Neace, Patrick A Joyce, Charlotte A Gaydos, James I A Huth, Lorelei A Mucci, Lisa B Signorello

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer causes & control : CCC, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Siobhan SutcliffeDivision of Public Health Sciences and the Alvin J. Siteman Cancer Center, Department of Surgery, Washington University School of Medicine, 660 S. Euclid Ave., Box 8100, Rm. 208S, St. Louis, MO, 63110, USA. sutcliffes@wudosis.wustl.edu.
John F AldereteSchool of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA, USA.
Calvin NeaceSchool of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA, USA.
Patrick A JoyceSchool of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA, USA.
Charlotte A GaydosDivision of Infectious Diseases, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
James I A HuthDepartment of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
Lorelei A MucciDepartment of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
Lisa B SignorelloDepartment of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
Harvard University · USWashington State University · USJohns Hopkins University · US

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
Southern Community Cohort StudyR01CA092447 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLOT, WILLIAM J., ZHENG, WEI · 2001 to 2015
$74.0M
NCI NIH HHS P30 CA091842NCI NIH HHS R01 CA092447
6 · The paper itself

Abstract

purposePrevious epidemiologic studies have observed positive associations between Trichomonas vaginalis (Tv) serostatus and both prostate cancer (PCa) risk and mortality. However, only a few small older studies have examined Tv antibody persistence over time, all of which were composed mainly of female patients. Therefore, we examined Tv antibody persistence over time, as well as intra-individual variability, among middle- to older-aged men in the Southern Community Cohort Study (SCCS).

methodsWe tested baseline and repeat plasma specimens (collected 1-3 years later) from 248 male participants for Tv antibodies. We used the same enzyme-linked immunosorbent assay as in previous studies of Tv serostatus and PCa.

resultsAt baseline, 46 (18.5 %) participants were seropositive for Tv infection. Seventy-six percent of these men were still seropositive 1-3 years later. A similar proportion of men "seroconverted" (4.0 %) as "seroreverted" (4.4 %), all of whom had absorbance values near the cutoff point for seropositivity. Overall, substantial agreement was observed between baseline and repeat serostatus (κ = 0.72, 95 % confidence interval 0.60-0.83).

conclusionTv seropositivity was largely persistent between plasma specimens collected 1-3 years apart from middle- to older-aged men. These high levels of persistence are similar to those observed for other sexually transmitted infections frequently investigated in relation to PCa.

Indexed as

AdultAgedAntibodies, ProtozoanCohort StudiesEnzyme-Linked Immunosorbent AssayHumansMaleMiddle AgedProstatic NeoplasmsRisk FactorsSex FactorsTime FactorsTrichomonas InfectionsTrichomonas vaginalisAntibodies, ProtozoanAntibodyMalesPersistenceReproducibilityTrichomonas vaginalis

Identifiers

PMID26223890
PMCPMC4567958
OpenAlexW1036618052

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.