ArticleAngewandte Chemie (International ed. in English)2015
Electrostatic Localization of RNA to Protocell Membranes by Cationic Hydrophobic Peptides.
Article in Angewandte Chemie (International ed. in English), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 71 citations in OpenAlex.
- The secret life of RNA and lipids.RNA biology · 2025Review
- Article
- From the RNA-Peptide World: Prebiotic Reaction Conditions Compatible with Lipid Membranes for the Formation of Lipophilic Random Peptides in the Presence of Short Oligonucleotides, and More.Life (Basel, Switzerland) · 2024Article
- An inorganic mineral-based protocell with prebiotic radiation fitness.Nature communications · 2023Article
- Self-organization of primitive metabolic cycles due to non-reciprocal interactions.Nature communications · 2023Article
- Adsorption/Desorption of Cationic-Hydrophobic Peptides on Zwitterionic Lipid Bilayer Is Associated with the Possibility of Proton Transfer.Antibiotics (Basel, Switzerland) · 2023Article
- Selective Synthesis of Lysine Peptides and the Prebiotically Plausible Synthesis of Catalytically Active Diaminopropionic Acid Peptide Nitriles in Water.Journal of the American Chemical Society · 2023Article
- It's Just a Phase: Exploring the Relationship Between mRNA, Biomolecular Condensates, and Translational Control.Frontiers in genetics · 2022Review
- Binding of Dipeptides to Fatty Acid Membranes Explains Their Colocalization in Protocells but Does Not Select for Them Relative to Unjoined Amino Acids.The journal of physical chemistry. B · 2021Article
- Activation chemistry drives the emergence of functionalised protocells.Chemical science · 2020Article
- Coordination-Cage-Catalysed Hydrolysis of Organophosphates: Cavity- or Surface-Based?Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- The role of sugar-backbone heterogeneity and chimeras in the simultaneous emergence of RNA and DNA.Nature chemistry · 2019Article
- Prebiotic amino acids bind to and stabilize prebiotic fatty acid membranes.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Selective incorporation of proteinaceous over nonproteinaceous cationic amino acids in model prebiotic oligomerization reactions.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Investigating Prebiotic Protocells for A Comprehensive Understanding of the Origins of Life: A Prebiotic Systems Chemistry Perspective.Life (Basel, Switzerland) · 2019Review
- DNA Length-dependent Division of a Giant Vesicle-based Model Protocell.Scientific reports · 2019Article
- Copying of Mixed-Sequence RNA Templates inside Model Protocells.Journal of the American Chemical Society · 2018Article
- Selective protein recognition in supported lipid bilayer arrays by tailored, dual-mode deep cavitand hosts.Soft matter · 2017Article
- Small and Random Peptides: An Unexplored Reservoir of Potentially Functional Primitive Organocatalysts. The Case of Seryl-Histidine.Life (Basel, Switzerland) · 2017Review
- Simple peptides derived from the ribosomal core potentiate RNA polymerase ribozyme function.Nature chemistry · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cooperative interactions between RNA and vesicle membranes on the prebiotic earth may have led to the emergence of primitive cells. The membrane surface offers a potential platform for the catalysis of reactions involving RNA, but this scenario relies upon the existence of a simple mechanism by which RNA could become associated with protocell membranes. Here, we show that electrostatic interactions provided by short, basic, amphipathic peptides can be harnessed to drive RNA binding to both zwitterionic phospholipid and anionic fatty acid membranes. We show that the association of cationic molecules with phospholipid vesicles can enhance the local positive charge on a membrane and attract RNA polynucleotides. This phenomenon can be reproduced with amphipathic peptides as short as three amino acids. Finally, we show that peptides can cross bilayer membranes to localize encapsulated RNA. This mechanism of polynucleotide confinement could have been important for primitive cellular evolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.