ArticleJournal of neurology2015
Elevated body temperature is linked to fatigue in an Italian sample of relapsing-remitting multiple sclerosis patients.
Article in Journal of neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 23 citations in OpenAlex.
- A randomized controlled trial of oral antipyretic treatment to reduce overheating during exercise in adults with multiple sclerosis.Journal of neurology · 2024Trial
- The pathophysiology of motor fatigue and fatigability in multiple sclerosis.Frontiers in neurology · 2022Review
- The importance of body core temperature evaluation in balneotherapy.International journal of biometeorology · 2022Review
- The Seasonal Fluctuation of Fatigue in Multiple Sclerosis.Frontiers in neurology · 2022Article
- Acute Thermoregulatory and Cardiovascular Response to Submaximal Exercise in People With Multiple Sclerosis.Frontiers in immunology · 2022Article
- Wearable biosensors to monitor disability in multiple sclerosis.Neurology. Clinical practice · 2017Review
- Diuretic-sensitive electroneutral NaThe Journal of physiology · 2017Article
- Subjective Cognitive Fatigue and Autonomic Abnormalities in Multiple Sclerosis Patients.Frontiers in neurology · 2017Article
- Uhthoff`s phenomenon 125 years later - what do we know today?Journal of medicine and lifeReview
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Elevated body temperature was recently reported for the first time in patients with relapsing-remitting multiple sclerosis (RRMS) relative to healthy controls. In addition, warmer body temperature was associated with worse fatigue. These findings are highly novel, may indicate a novel pathophysiology for MS fatigue, and therefore warrant replication in a geographically separate sample. Here, we investigated body temperature and its association to fatigue in an Italian sample of 44 RRMS patients and 44 age- and sex-matched healthy controls. Consistent with our original report, we found elevated body temperature in the RRMS sample compared to healthy controls. Warmer body temperature was associated with worse fatigue, thereby supporting the notion of endogenous temperature elevations in patients with RRMS as a novel pathophysiological factor underlying fatigue. Our findings highlight a paradigm shift in our understanding of the effect of heat in RRMS, from exogenous (i.e., Uhthoff's phenomenon) to endogenous. Although randomized controlled trials of cooling treatments (i.e., aspirin, cooling garments) to reduce fatigue in RRMS have been successful, consideration of endogenously elevated body temperature as the underlying target will enhance our development of novel treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.