Evidence map›Paper›PMID 26223550›Full record

ArticleMicroscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada2015

Multiplexed TEM Specimen Preparation and Analysis of Plasmonic Nanoparticles.

Sean K Mulligan, Jeffrey A Speir, Ivan Razinkov, Anchi Cheng, John Crum, Tilak Jain, Erika Duggan, Er Liu, John P Nolan, Bridget Carragher and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sean K Mulligan *The National Resource for Automated Molecular Microscopy, La Jolla, California, 92037, USA.
Jeffrey A Speir *The National Resource for Automated Molecular Microscopy, La Jolla, California, 92037, USA.
Ivan Razinkov *The National Resource for Automated Molecular Microscopy, La Jolla, California, 92037, USA.
Anchi ChengThe National Resource for Automated Molecular Microscopy, La Jolla, California, 92037, USA.
John CrumThe National Resource for Automated Molecular Microscopy, La Jolla, California, 92037, USA.
Tilak JainThe National Resource for Automated Molecular Microscopy, La Jolla, California, 92037, USA.
Erika DugganScintillon Institute, San Diego, California, 92121, USA.
Er LiuLa Jolla Bioengineering Institute, San Diego, California, 92121, USA.
John P NolanScintillon Institute, San Diego, California, 92121, USA.
Bridget CarragherThe National Resource for Automated Molecular Microscopy, La Jolla, California, 92037, USA.
Clinton S PotterThe National Resource for Automated Molecular Microscopy, La Jolla, California, 92037, USA.

Funding

TRD #3: An automated and streamlined pipeline for in-situ molecular microscopyP41GM103310 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2012 to 2021
$14.7M
Raman Flow Cytometry for Diagnostics and Drug DiscoveryR01EB003824 · NIBIB · SCINTILLON INSTITUTE FOR PHOTOBIOLOGY · PI NOLAN, JOHN P · 2004 to 2014
$12.2M
High Thruput EM Sample Preparation for Structural BiologyR01GM103966 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI POTTER, CLINTON S · 2013 to 2016
$1.6M
A Helical Crystallization Pipeline for Membrane Protein Structure by TEMR01GM095573 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI CARRAGHER, BRIDGET OLIVIA · 2010 to 2013
$1.6M
NIBIB NIH HHS EB03824NIBIB NIH HHS R01 EB003824NIGMS NIH HHS GM103310NIGMS NIH HHS GM103966NIGMS NIH HHS P41 GM103310NIGMS NIH HHS R01 GM095573NIGMS NIH HHS R01 GM103966
6 · The paper itself

Abstract

We describe a system for rapidly screening hundreds of nanoparticle samples using transmission electron microscopy (TEM). The system uses a liquid handling robot to place up to 96 individual samples onto a single standard TEM grid at separate locations. The grid is then transferred into the TEM and automated software is used to acquire multiscale images of each sample. The images are then analyzed to extract metrics on the size, shape, and morphology of the nanoparticles. The system has been used to characterize plasmonically active nanomaterials.

Indexed as

High-Throughput Screening AssaysMicroscopy, Electron, TransmissionNanoparticlesRoboticsSpecimen HandlingautomationnanoparticlesTEM

Identifiers

PMID26223550
PMCPMC4701052

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.