Evidence map›Paper›PMID 26223484›Full record

ArticleSleep & breathing = Schlaf & Atmung2016

CPAP therapy induces favorable short-term changes in epicardial fat thickness and vascular and metabolic markers in apparently healthy subjects with obstructive sleep apnea-hypopnea syndrome (OSAHS).

Konstantinos Kostopoulos, Emmanouil Alhanatis, Konstantinos Pampoukas, Georgios Georgiopoulos, Andromahi Zourla, Athanasios Panoutsopoulos, Anastasios Kallianos, Lemonia Velentza, Paul Zarogoulidis, Georgia Trakada

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Article in Sleep & breathing = Schlaf & Atmung, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 3 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Konstantinos KostopoulosTherapeutic Clinic Alexandra, Hospital University of Athens, Athens, Greece.
Emmanouil AlhanatisTherapeutic Clinic Alexandra, Hospital University of Athens, Athens, Greece.
Konstantinos PampoukasTherapeutic Clinic Alexandra, Hospital University of Athens, Athens, Greece.
Georgios GeorgiopoulosTherapeutic Clinic Alexandra, Hospital University of Athens, Athens, Greece.
Andromahi ZourlaTherapeutic Clinic Alexandra, Hospital University of Athens, Athens, Greece.
Athanasios PanoutsopoulosTherapeutic Clinic Alexandra, Hospital University of Athens, Athens, Greece.
Anastasios KallianosTherapeutic Clinic Alexandra, Hospital University of Athens, Athens, Greece.
Lemonia VelentzaTherapeutic Clinic Alexandra, Hospital University of Athens, Athens, Greece.
Paul ZarogoulidisPulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece. pzarog@hotmail.com.
Georgia TrakadaTherapeutic Clinic Alexandra, Hospital University of Athens, Athens, Greece.
National and Kapodistrian University of Athens · GRAlexandra Hospital · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObstructive sleep apnea-hypopnea syndrome (OSAHS) is an independent risk factor for hypertension, coronary artery disease, and diabetes mellitus. Epicardial fat has been recently recognized as a new risk factor and active participant on cardiometabolic risk. The aim of this study was to assess an independent relationship between sleep apnea severity, metabolic and vascular markers, and epicardial fat, at baseline and after 3 months of continuous positive airway pressure (CPAP) therapy. MATERIALS AND

methodOur study group consisted of 48 patients with suspected OSAHS and no prior history of cardiovascular disease or diabetes mellitus. All patients underwent full overnight polysomnography. Thickness of epicardial and visceral adipose tissue, brachial artery flow-mediated dilation (FMD), carotid intima media thickness (cIMT), pulse wave velocity (PWV), plasma C-reactive protein (CRP) levels, fasting glucose levels, HbA1c, homeostatic model assessment of insulin resistance index (HOMA), and lipid profile were measured at baseline and after 3 months of CPAP use in patients with moderate to severe OSAHS.

resultsIn OSAHS patients (Apnea-hypopnea index (AHI) ≥15/h, N = 28), epicardial fat correlated with fasting glucose (rho = 0.406, p = 0.04) and HOMA (rho = 0.525, p = 0.049) but was not associated with visceral fat (rho = 0.126, p = 0.595). Epicardial adipose tissue (EAT) (p = 0.022) increased across AHI severity along with PWV (p = 0.045) and carotid intima media thickness (IMT) (p = 0.034) while FMD (p = 0.017) decreased. Therapy with CPAP reduced both epicardial (p < 0.001) and visceral fat (p = 0.001). Alterations in epicardial fat across the follow-up were associated with changes in PWV (p = 0.026) and HOMA (p = 0.037) independently of major confounders.

conclusionsEpicardial fat thickness was associated with OSA severity and may be an additional marker of cardiovascular risk as well as of future diabetes in these patients. CPAP therapy reduced epicardial fat, suggesting its potentially beneficial role in reducing cardiometabolic risk in OSA patients.

Indexed as

Continuous Positive Airway PressureAdipose TissueBlood GlucoseCarotid Intima-Media ThicknessEnergy MetabolismFollow-Up StudiesHemodynamicsInsulin ResistanceIntra-Abdominal FatPericardiumPolysomnographyPulse Wave AnalysisSleep Apnea, ObstructiveVasodilationBlood GlucoseCardiometabolic riskContinuous positive airways pressure (CPAP)Epicardial adipose tissue (EAT)Insulin resistance (HOMA)Obstructive sleep apnea syndrome (OSAHS)Pulse wave velocity (PWV)

Identifiers

PMID26223484
OpenAlexW1015344383

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.