ArticleBehavior genetics2016
Cohort Effects in the Genetic Influence on Smoking.
Article in Behavior genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05046535 (The Effect of Cigarette Smoke on Sleep Quality and Physical Activity in People With Multiple Sclerosis), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Cigarette Smoke on Sleep Quality and Physical Activity in People With Multiple Sclerosis
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic Review of Polygenic Gene-Environment Interaction in Tobacco, Alcohol, and Cannabis Use.Behavior genetics · 2019Pooled it
- Peer influence on obesity: Evidence from a natural experiment of a gene-environment interaction.Social science research · 2021Trial
- Exploring links between health and the genetic risk for smoking.SSM - population health · 2026Article
- Raising the Floor? Genetic Influences on Educational Attainment Through the Lens of the Evolving Swedish Welfare State.Behavior genetics · 2025Article
- Single Cell Transcriptomics Genomics Based on Machine Learning Algorithm: Constructing and Validating Neutrophil Extracellular Trap Gene Model in COPD.International journal of general medicine · 2025Article
- Cohort Effects on Tobacco Consumption and Its Genetic and Environmental Variance Among Finnish Adults Born Between 1880 and 1957.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024Article
- Analysis of Sex-Specific Gene-by-Cohort and Genetic Correlation-by-Cohort Interaction in Educational and Reproductive Outcomes Using the UK Biobank Data.Journal of health and social behavior · 2024Article
- Deep sequencing of candidate genes identified 14 variants associated with smoking abstinence in an ethnically diverse sample.Scientific reports · 2024Article
- Challenges in studying the interplay of genes and environment. A study of childhood financial distress moderating genetic predisposition for peak smoking.Journal Of Economic Psychology · 2023Article
- Gene-environment interactions and the case of body mass index and obesity: How much do they matter?PNAS nexus · 2023Article
- Evaluating the Continued Integration of Genetics into Medical Sociology.Journal of health and social behavior · 2021Article
- Genes Related to Education Predict Frailty Among Older Adults in the United States.The journals of gerontology. Series B, Psychological sciences and social sciences · 2021Article
- Article
- A Simulation Study of Bootstrap Approaches to Estimate Confidence Intervals in DeFries-Fulker Regression Models (with Application to the Heritability of BMI Changes in the NLSY).Behavior genetics · 2020Article
- Education, Smoking, and Cohort Change: Forwarding a Multidimensional Theory of the Environmental Moderation of Genetic Effects.American sociological review · 2018Article
- Genetic Risks for Chronic Conditions: Implications for Long-term Wellbeing.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Article
- Effects of Social Attitude Change on Smoking Heritability.Behavior genetics · 2018Article
- Genetic Predisposition to Obesity and Medicare Expenditures.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Mortality selection in a genetic sample and implications for association studies.International journal of epidemiology · 2017Article
- Changing Polygenic Penetrance on Phenotypes in the 20(th) Century Among Adults in the US Population.Scientific reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
We examine the hypothesis that the heritability of smoking has varied over the course of recent history as a function of associated changes in the composition of the smoking and non-smoking populations. Classical twin-based heritability analysis has suggested that genetic basis of smoking has increased as the information about the harms of tobacco has become more prevalent-particularly after the issuance of the 1964 Surgeon General's Report. In the present paper we deploy alternative methods to test this claim. We use data from the Health and Retirement Study to estimate cohort differences in the genetic influence on smoking using both genomic-relatedness-matrix restricted maximum likelihood and a modified DeFries-Fulker approach. We perform a similar exercise deploying a polygenic score for smoking using results generated by the Tobacco and Genetics consortium. The results support earlier claims that the genetic influence in smoking behavior has increased over time. Emphasizing historical periods and birth cohorts as environmental factors has benefits over existing GxE research. Our results provide additional support for the idea that anti-smoking policies of the 1980s may not be as effective because of the increasingly important role of genotype as a determinant of smoking status.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.