ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2016
Zonal differences in meniscus MR relaxation times in response to in vivo static loading in knee osteoarthritis.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence of knee osteoarthritis features on magnetic resonance imaging in asymptomatic uninjured adults: a systematic review and meta-analysis.British journal of sports medicine · 2019Pooled it
- Ultrashort echo time adiabatic TMagnetic resonance imaging · 2021Article
- Prevalence of abnormal findings in 230 knees of asymptomatic adults using 3.0 T MRI.Skeletal radiology · 2020Article
- Functional MRI Mapping of Human Meniscus Functionality and its Relation to Degeneration.Scientific reports · 2020Observational
- Magnetic resonance imaging (MRI) studies of knee joint under mechanical loading: Review.Magnetic resonance imaging · 2020Review
- Degeneration Affects Three-Dimensional Strains in Human Menisci:Frontiers in bioengineering and biotechnology · 2020Article
- Biexponential TJournal of magnetic resonance imaging : JMRI · 2019Article
- Methods for evaluating effects of unloader knee braces on joint health: a review.Biomedical engineering letters · 2019Review
- Using multidimensional topological data analysis to identify traits of hip osteoarthritis.Journal of magnetic resonance imaging : JMRI · 2018Article
- Article
- Imaging and TMagnetic resonance in medicine · 2017Article
- T1rho and T2 relaxation times of the normal adult knee meniscus at 3T: analysis of zonal differences.BMC musculoskeletal disorders · 2017Article
- Ex vivo quantitative multiparametric MRI mapping of human meniscus degeneration.Skeletal radiology · 2016Observational
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
This study assessed the effects of static loading on MRI relaxation times of menisci in individuals with and without radiographic knee OA. High-resolution fast spin-echo (FSE) and T(1ρ)/T(2) relaxation time MR sequences were obtained with and without loading at 50% body weight in 124 subjects. T(1ρ)/T(2) relaxation times were calculated in menisci, and meniscus lesions were assessed through clinical grading. Student's t-test compared OA and control unloaded relaxation times as well as within-group changes with loading, Generalized Linear Models evaluated zonal variation, and ANCOVA compared loading response between groups. Unloaded T(1ρ) and T(2) in the middle and inner zones of the lateral anterior horn and outer zone of the medial posterior horn were significantly higher in OA and suggest that meniscal OA change occurs unevenly. Zonal T(1ρ) and T(2) showed differing patterns between anterior and posterior horns, suggesting differences in macromolecular organization. Significant increases with loading were seen largely in the T(2) of controls and less frequently in subjects with OA. In the medial posterior horn, T(1ρ) and T(2) decreased with loading in OA but changed negligibly in controls; these significantly different loading responses between groups may indicate load transmission failure in OA menisci.
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