Evidence map›Paper›PMID 26223412›Full record

ArticleNanomedicine (London, England)2015

Bioactive nanoparticles improve calcium handling in failing cardiac myocytes.

Joshua T Maxwell, Inthirai Somasuntharam, Warren D Gray, Ming Shen, Jason M Singer, Bo Wang, Talib Saafir, Brian H Crawford, Rong Jiang, Niren Murthy and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomedicine (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Joshua T MaxwellWallace H Coulter Department of Biomedical Engineering, Emory University School of Medicine, 1648 Pierce Dr NE, Atlanta, GA 30307, USA.
Inthirai SomasuntharamWallace H Coulter Department of Biomedical Engineering, Emory University School of Medicine, 1648 Pierce Dr NE, Atlanta, GA 30307, USA.
Warren D GrayWallace H Coulter Department of Biomedical Engineering, Emory University School of Medicine, 1648 Pierce Dr NE, Atlanta, GA 30307, USA.
Ming ShenDivision of Pediatric Cardiology, Department of Pediatrics, Emory University School of Medicine, 1648 Pierce Dr NE, Atlanta, GA 30307, USA.
Jason M SingerDivision of Pediatric Cardiology, Department of Pediatrics, Emory University School of Medicine, 1648 Pierce Dr NE, Atlanta, GA 30307, USA.
Bo WangDivision of Pediatric Cardiology, Department of Pediatrics, Emory University School of Medicine, 1648 Pierce Dr NE, Atlanta, GA 30307, USA.
Talib SaafirDivision of Pediatric Cardiology, Department of Pediatrics, Emory University School of Medicine, 1648 Pierce Dr NE, Atlanta, GA 30307, USA.
Brian H CrawfordDivision of Pediatric Cardiology, Department of Pediatrics, Emory University School of Medicine, 1648 Pierce Dr NE, Atlanta, GA 30307, USA.
Rong JiangDivision of Pediatric Cardiology, Department of Pediatrics, Emory University School of Medicine, 1648 Pierce Dr NE, Atlanta, GA 30307, USA.
Niren MurthyDepartment of Bioengineering, University of California Berkeley, Berkeley, CA, USA.
Michael E DavisWallace H Coulter Department of Biomedical Engineering, Emory University School of Medicine, 1648 Pierce Dr NE, Atlanta, GA 30307, USA.
Mary B WagnerDivision of Pediatric Cardiology, Department of Pediatrics, Emory University School of Medicine, 1648 Pierce Dr NE, Atlanta, GA 30307, USA.
Children's Healthcare of Atlanta · USEmory University · USThe Wallace H. Coulter Department of Biomedical Engineering · USUniversity of California, Berkeley · US

Funding

Polyketals to encapsulate a small molecule p38 inhibitor for cardiac regenerationR01HL090601 · NHLBI · EMORY UNIVERSITY · PI DAVIS, MICHAEL E · 2009 to 2013
$1.8M
NHLBI NIH HHS HHSN268201000043CNHLBI NIH HHS HL090601NHLBI NIH HHS R01 HL090601PHS HHS HHSN268201000043C
6 · The paper itself

Abstract

aimsTo evaluate the ability of N-acetylglucosamine (GlcNAc) decorated nanoparticles and their cargo to modulate calcium handling in failing cardiac myocytes (CMs). MATERIALS &

methodsPrimary CMs isolated from normal and failing hearts were treated with GlcNAc nanoparticles in order to assess the ability of the nanoparticles and their cargo to correct dysfunctional calcium handling in failing myocytes. RESULTS &

conclusionGlcNAc particles reduced aberrant calcium release in failing CMs and restored sarcomere function. Additionally, encapsulation of a small calcium-modulating protein, S100A1, in GlcNAc nanoparticles also showed improved calcium regulation. Thus, the development of our bioactive nanoparticle allows for a 'two-hit' treatment, by which the cargo and also the nanoparticle itself can modulate intracellular protein activity.

Indexed as

AcetylglucosamineCalciumCalcium SignalingHeart FailureHumansMyocytes, CardiacNanoparticlesS100 ProteinsSarcomeresAcetylglucosamineCalciumS100A1 proteinS100 Proteinsbiomoleculescalcium handlingcardiac myocytesencapsulationGlcNAcheart failurenanoparticlesS100A1

Identifiers

PMID26223412
PMCPMC4698160
OpenAlexW2176476491

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.