ArticleJournal of orthopaedic surgery and research2015
Are biological agents toxic to human chondrocytes and osteocytes?
Article in Journal of orthopaedic surgery and research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
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- Effect of naproxen on proliferation and differentiation of primary cell cultures isolated from human cartilage tissue.Experimental and therapeutic medicine · 2018Article
- The association between different molecular weights of hyaluronic acid and CHAD, HIF-1α, COL2A1 expression in chondrocyte cultures.Experimental and therapeutic medicine · 2018Article
- Hydroxylated Fullerene: A Stellar Nanomedicine to Treat Lumbar Radiculopathy via Antagonizing TNF-ACS biomaterials science & engineering · 2018Article
- Iopromide- and gadopentetic acid-derived preparates used in MR arthrography may be harmful to chondrocytes.Journal of orthopaedic surgery and research · 2017Article
- Curcumin alleviates lumbar radiculopathy by reducing neuroinflammation, oxidative stress and nociceptive factors.European cells & materials · 2017Article
- Are We Using Slow-Acting Symptomatic Chondroprotective Drugs Conscious Enough?The open orthopaedics journal · 2017Article
- Can a Biodegradable Implanted Bilayered Drug Delivery System Loaded with BMP-2/BMP-12 Take an Effective Role in the Biological Repair Process of Bone-Tendon Injuries? A Preliminary Report.Journal of pharmaceutics · 2017Article
- A practical way to prepare primer human chondrocyte culture.Journal of orthopaedics · 2016Article
- Assessing the negative impact of phenyl alkanoic acid derivative, a frequently prescribed drug for the suppression of pain and inflammation, on the differentiation and proliferation of chondrocytes.Journal of orthopaedic surgery and research · 2016Article
- Are We Economically Efficient Enough to Increase the Potential ofThe open orthopaedics journal · 2016Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of the present study is to investigate the effects of biological agents (BAs) on human chondrocytes and osteocytes in vitro.
methodsPrimary cell cultures obtained from gonarthrosis patients were divided into four groups, two of which were designated as control cultures of chondrocyte and osteocyte, and the other two groups were exposed to BAs administered via the culture medium. Cultured cells were characterized by immunophenotyping. Before and after administration of the agents, the cultures were observed by inverted and environmental scanning electron microscopy (ESEM). The number of live cells and the proliferation rate were monitored by MTT assay.
resultsRituximab and adalimumab were the least toxic agents to chondrocytes, whereas adalimumab and etanercept were to osteocytes.
conclusionDuring periods of intense active inflammation, the concentration of the preferred BAs after inhibition of inflammation needs to be emphasized when their effects on cartilage and bone tissue are considered at the cellular level if the clinical practice is to continue.
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