ArticleJournal of human hypertension2016
Relationship between blood pressure variability and renal activity of the renin-angiotensin system.
Article in Journal of human hypertension, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Effect of angiotensin II receptor blocker and salt supplementation on short-term blood pressure variability in type 2 diabetes.Journal of human hypertension · 2020Trial
- Ambulatory Blood Pressure Variability, Progression of Kidney Disease, and Cardiovascular Outcomes in the Chronic Renal Insufficiency Cohort.American journal of hypertension · 2025Observational
- Assessing the relationship between short-term blood pressure variability and glycation profile in young and middle-aged nondiabetic hypertensive individuals.Journal of hypertension · 2025Observational
- Biological effects of diesel exhaust inhalation. III cardiovascular function.Inhalation toxicology · 2024Article
- Short-term blood pressure variability as a potential therapeutic target for kidney disease.Clinical hypertension · 2023Review
- Article
- Short-Term Systolic Blood Pressure Variability and Kidney Disease Progression in Patients With Chronic Kidney Disease: Results From C-STRIDE.Journal of the American Heart Association · 2020Article
- Twenty-four-hour systolic blood pressure variability and renal function decline in elderly male hypertensive patients with well-controlled blood pressure.Clinical interventions in aging · 2018Observational
- Positive association between KCNJ5 rs2604204 (A/C) polymorphism and plasma aldosterone levels, but also plasma renin and angiotensin I and II levels, in newly diagnosed hypertensive Chinese: a case-control study.Journal of human hypertension · 2017Article
- Ambulatory Blood Pressure in Chronic Kidney Disease: Ready for Prime Time?Kidney international reports · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
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Abstract
Local renin-angiotensin system (RAS) activity in the kidneys is a pathogenetic factor in patients with primary hypertension. This study aimed to determine the relationship between local kidney RAS activity and blood pressure variability, as the literature currently lacks any such study. The study included 73 consecutive primary hypertensive patients. All patients underwent 24-h ambulatory blood pressure monitoring to determine the average real variability (ARV) index, as an indicator of blood pressure variability. Local RAS activity was determined using the urine angiotensinogen/creatinine (UAGT/UCre) ratio. The high UAGT/UCre ratio group had significantly higher mean 24-h systolic ARV than the low UAGT/UCre ratio group (13.2±3.4 vs 11.0±2.6, P=0.003). Similarly, the high UAGT/UCre ratio group had significantly higher mean 24-h diastolic ARV than the low UAGT/UCre ratio group (10.8±3.2 vs 8.7±2.2, P=0.001). Multivariate regression analysis showed that Log(UAGT/UCre) was an independent predictor of both 24-h diastolic ARV and 24-h systolic ARV. Local RAS activity in the kidneys might have a role in blood pressure variability. On the basis of these findings, we think that additional prospective studies are needed to more fully discern the effect of local RAS activity on blood pressure variability.
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