Evidence map›Paper›PMID 26223338›Full record

ArticleIrish journal of medical science2016

Evaluation of lead and essential elements in whole blood during pregnancy: a cross-sectional study.

K Liu, X Mao, J Shi, Y Lu, C Liu

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Article in Irish journal of medical science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 3 pooled it
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Pooled it
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  3. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

K LiuDepartment of Clinical Laboratory, State Key Laboratory of Reproductive Medicine, Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, Nanjing, 210029, China.
X MaoEndocrine and Diabetes Center, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing University of Traditional Chinese Medicine, Jiangsu Branch of China Academy of Chinese Medical Science, No. 100 Hongshang Road, Nanjing, 210028, China.
J ShiDepartment of Maternity and Child Health Care, Nanjing Maternity and Child Health Care Hospital, Nanjing, 210004, China.
Y LuDepartment of Obstetrical, Nanjing Maternity and Child Health Care Hospital, Nanjing, 210004, China.
C LiuEndocrine and Diabetes Center, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing University of Traditional Chinese Medicine, Jiangsu Branch of China Academy of Chinese Medical Science, No. 100 Hongshang Road, Nanjing, 210028, China. Jsdxjsxynj@163.com.
Nanjing Maternity and Child Health Care Hospital · CNJiangsu Province Hospital · CNNanjing University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimPhysiological concentrations of some elements fluctuate during pregnancy due to the increased requirements of growing fetus and changes in the maternal physiology. The aim of the study is to evaluate the distribution at different stages of pregnancy in healthy Chinese women and to show the association between trace elements and gestational age-specific reference intervals.

methodsA cross-sectional study was performed in 1089 pregnant women and 677 nonpregnant control women. Five element concentrations, including Cu, Zn, Ca, Mg, Pb in the blood were determined by atomic absorption spectrometry. Spearman's rank correlation test was used to assess the relationship between weeks of gestation and blood element concentrations.

resultsThe mean levels of Cu and Mg were 23.64 ± 4.69 μmol/L and 1.36 ± 0.12 mmol/L, respectively, in the control women. While 0.68 % of all pregnant women showed Cu levels below the normal ranges, the levels of Mg were comparable in different groups. Though the overall mean blood zinc and Ca concentrations (83.84 ± 17.50 μmol/L and 1.60 ± 0.15 mmol/L, respectively) increased gradually with the progress of gestation, the Zn and Ca deficiency levels (16.6 and 3.6 %, respectively) decreased with the advance of gestation. Compared with nonpregnant group, the concentrations of Cu, Zn, Ca, Mg, Pb during the different stages of pregnancy, as a whole, were significantly different. Positive correlations were observed between weeks of gestation and blood Cu, Ca, Pb concentrations (r = 0.301, 0.221, 0.223; P < 0.05). There was a negative correlation blood Mg concentrations and weeks of gestation (r = -0.321; P < 0.05). A weak positive correlation was noted between Zn concentrations and weeks of gestation (r = 0.125; P < 0.05).

conclusionThe importance of Cu and Mg deficiency and supplementation is well realized, but, Zn/Ca deficiency and Pb exposure is still exist; the overall deficiency of pregnant women was not so optimistic. During pregnancy, the established reference values will provide an important guidance for the reasonable supplementation of essential elements and surveillance of lead overexposure.

Indexed as

AdultCalciumCase-Control StudiesCopperCross-Sectional StudiesFemaleGestational AgeHumansMagnesiumPregnancyPregnancy Trimester, FirstPregnancy Trimester, SecondReference ValuesSpectrophotometry, AtomicTrace ElementsYoung AdultCalciumCopperMagnesiumTrace ElementsZincBlood copperCalciumDuration of pregnancyLeadMagnesiumZinc

Identifiers

PMID26223338
OpenAlexW1033708671

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.